FST and BMP5

Number of citations of the paper that reports this interaction (PubMedID 11580864)
24

Data Source:
HPRD (in vivo)

		FST	BMP5
Description		follistatin	bone morphogenetic protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm	Cellular_component Extracellular Space Vesicle
	Molecular Function	Protein Binding Activin Receptor Antagonist Activity Heparan Sulfate Proteoglycan Binding Activin Binding	Cytokine Activity Protein Binding Growth Factor Activity BMP Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Hematopoietic Progenitor Cell Differentiation Multicellular Organism Development Gamete Generation Pattern Specification Process Female Gonad Development Cell Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Hair Follicle Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Keratinocyte Proliferation Negative Regulation Of Cell Differentiation Positive Regulation Of Hair Follicle Development	Skeletal System Development Ossification Endocardial Cushion Formation Type B Pancreatic Cell Development Pericardium Morphogenesis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Neural Fold Elevation Formation BMP Signaling Pathway Hindbrain Development Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Pharyngeal System Development SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Negative Regulation Of Mononuclear Cell Migration Positive Regulation Of Dendrite Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Allantois Development Negative Regulation Of Cortisol Biosynthetic Process
Pathways		Antagonism of Activin by Follistatin
Drugs		D-Myo-Inositol-Hexasulphate
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Alzheimer's disease (late onset) ( 30820047) Central corneal thickness ( 32528159) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Height ( 31562340) High-grade serous ovarian cancer ( 31469419) Intraocular pressure ( 29617998 29235454) Keratoconus ( 33649486) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Midgestational circulating levels of PCBs ( 28235828) Optic disc size ( 31809533) Refractive error ( 32231278) Vaginal microbiome composition (community state type) ( 32723796)	Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549 28869591) Lean body mass ( 28552196) Schizophrenia ( 34099189) Zinc levels ( 26025379)
Interacting Genes		14 interacting genes: BEX2 BMP5 C8orf33 CATSPER1 CREB5 FN1 HOXA1 INHA INHBA INHBE MEST TK1 TXN ZNF587	5 interacting genes: BMPR1A CHRDL2 FST MEOX2 NOG
Entrez ID		10468	653
HPRD ID		00641	00210
Ensembl ID		ENSG00000134363	ENSG00000112175
Uniprot IDs		A0A024QZU6 P19883	A8K694 M9VUD0 P22003
PDB IDs		2B0U 2P6A 3HH2 5JHW
Enriched GO Terms of Interacting Partners?
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