TAB1 and HNRNPR

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		TAB1	HNRNPR
Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 1	heterogeneous nuclear ribonucleoprotein R
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GO Annotations	Cellular Component	Nucleus Cytosol Endosome Membrane Nuclear Speck Protein-containing Complex	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Endoplasmic Reticulum Dendrite Growth Cone Axon Terminus Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Phosphatase Activity Kinase Activator Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase P38 Binding	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding
	Biological Process	In Utero Embryonic Development Heart Morphogenesis Cardiac Septum Development Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Lung Development Aorta Development Positive Regulation Of MAP Kinase Activity Coronary Vasculature Development	MRNA Splicing, Via Spliceosome MRNA Processing Circadian Rhythm Negative Regulation Of Catalytic Activity MRNA Destabilization
Pathways		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs		Manganese
Diseases
GWAS		Factor VIII levels ( 30586737) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Schizophrenia ( 29483656) Serum alkaline phosphatase levels ( 33547301) Sleep duration (short sleep) ( 30846698) vWF levels ( 30586737) Waist circumference ( 28552196)	Hip circumference adjusted for BMI ( 34021172) Monocyte percentage of white cells ( 32888494)
Interacting Genes		79 interacting genes: AATK ACAP3 ARAP1 ASRGL1 BMPR1A C9orf78 CARD11 CASP6 CDK5RAP3 CFL1 CKB CORO1A CXCL16 DBN1 DVL2 EGFR EPRS1 ERBB4 FADD FN1 GIT1 HMGXB4 HNRNPR IFT27 IKBKG ITCH KDELR3 KIFC2 LAP3 LCMT1 LGALS7 LGALS7B LNX2 MAP3K1 MAP3K7 MAPK11 MAPK14 MAPKAPK5 MICAL1 MON1A MTG2 NR2C2 NXPH3 OGT PDCD6IP PHACTR3 PHC2 POLDIP2 POLR3D PPP1R7 PPP2CB PPP2R1A PRKAR1A PTPMT1 RBX1 ROR2 RPL10 RPLP1 SERPINA4 SMAD6 SMAD7 SMURF1 SNRNP35 TAB2 TAB3 TOM1 TRAF2 TRAF6 TRIP6 TRPC4AP TSSC4 UBC URB1 WDCP WTAP XIAP XPO7 YWHAG ZMYND11	88 interacting genes: ANKRD28 BMPR2 BRD4 FARSA FXR2 H3-4 IL7R MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFE2L2 OGT PCDHB14 PRMT1 RASD1 RPL26 SMN1 SUMO2 TAB1
Entrez ID		10454	10236
HPRD ID		04012	06228
Ensembl ID		ENSG00000100324	ENSG00000125944
Uniprot IDs		A8K6K3 Q15750	B4DMB1 B4DMD1 B4DT28 O43390 Q0VGD6 Q6MZS5
PDB IDs		2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L52 4L53 4O91 5DIY 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5NZZ 5O90 5V5N 5VVU	2DK2
Enriched GO Terms of Interacting Partners?
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