TUBB4B and PTPRE

		TUBB4B	PTPRE
Description		tubulin beta 4B class IVb	protein tyrosine phosphatase receptor type E
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding MHC Class I Protein Binding Unfolded Protein Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Natural Killer Cell Mediated Cytotoxicity	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		Albendazole Mebendazole Epothilone D Patupilone Oxibendazole CYT997 Phenethyl Isothiocyanate	Alendronic acid Tiludronic acid
Diseases
GWAS			Response to amphetamines ( 22952603) Select biomarker traits ( 17903293) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		24 interacting genes: ACD CDKN2A DAPK1 DLEU1 DLST ENOX2 LINC01554 NEAT1 NELFB OGT POT1 PSME1 PTEN PTPRE PTPRF SCG2 SOCS6 SOCS7 SPACA9 SUMO2 TERF1 TINF2 TSC1 TUBG1	12 interacting genes: FGFR2 FYN GRB2 KCNA5 KCNB1 MAPK1 MAPK3 PTPRD PTPRS SRC TUBB4B YES1
Entrez ID		10383	5791
HPRD ID		04043	02956
Ensembl ID		ENSG00000188229	ENSG00000132334
Uniprot IDs		P68371	A8K2Z9 P23469 Q96P81
PDB IDs			2JJD 6D3F 6D4D 6D4F
Enriched GO Terms of Interacting Partners?
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