TUBB3 and GZMK

Number of citations of the paper that reports this interaction (PubMedID 19059912)
25

Data Source:
BioGRID (enzymatic study)

		TUBB3	GZMK
Description		tubulin beta 3 class III	granzyme K
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Lamellipodium Filopodium Axon Dendrite Growth Cone Neuronal Cell Body Extracellular Exosome Cell Periphery	Extracellular Region
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Peptide Binding Netrin Receptor Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Axon Guidance Netrin-activated Signaling Pathway Dorsal Root Ganglion Development	Proteolysis
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Left-handedness ( 32989287) Leftâ€“right brain asymmetry ( 33723403) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)	Blood protein levels ( 30072576 29875488)
Interacting Genes		42 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDC42 CDKN1A DDX39B DUX4 EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 LINC01554 MAP7D3 MAPT MRPL28 MTCL1 MTDH MVD OGT PHIP PIEZO1 PLK1 PRDM7 RCC1 RILPL2 ROBO1 SCGN SEL1L3 SLC7A5 SMN1 SPTSSA TCF25 TERF1 TF TK1 TPTE TRAPPC2L	13 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TMBIM6 TUBB3 UFD1 VCP
Entrez ID		10381	3003
HPRD ID		04044	02872
Ensembl ID		ENSG00000258947	ENSG00000113088
Uniprot IDs		Q13509 Q53G92	P49863
PDB IDs		5IJ0 5IJ9 5JCO 6E7B 6S8L 6WSL	1MZA 1MZD
Enriched GO Terms of Interacting Partners?
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