RRAGB and RPTOR

Number of citations of the paper that reports this interaction (PubMedID 24337580)
30

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RRAGB	RPTOR
Description		Ras related GTP binding B	regulatory associated protein of MTOR complex 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Cytosol Gtr1-Gtr2 GTPase Complex	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Dendrite TORC1 Complex Neuronal Cell Body
	Molecular Function	GTPase Activity Protein Binding GTP Binding Guanyl Ribonucleotide Binding GTPase Binding	RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Protein-containing Complex Binding 14-3-3 Protein Binding
	Biological Process	Cellular Response To Starvation Regulation Of Autophagy Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Protein Localization Cellular Response To Amino Acid Stimulus Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell Size Cellular Response To Starvation Response To Xenobiotic Stimulus Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Social Behavior TORC1 Signaling Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Male-pattern baldness ( 27182965) Prostate-specific antigen levels ( 28139693) Smoking initiation ( 24665060)	Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)
Interacting Genes		6 interacting genes: APP DEPDC5 MTOR RPTOR RRAGC RRAGD	30 interacting genes: BAHCC1 CBX8 CCDC40 CILK1 DCXR DUXAP9 EIF4EBP1 EIF4EBP2 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NRBF2 PLD2 PRKAA1 PRKAA2 RAP1B RHEB RNF213 RPS6KA1 RPS6KB1 RRAGB TNRC6C USP36 WDR45B WIPI2
Entrez ID		10325	57521
HPRD ID		06710	06184
Ensembl ID		ENSG00000083750	ENSG00000141564
Uniprot IDs		Q5VZM2	Q6DKI0 Q8N122
PDB IDs			5H64 6BCU 6BCX 6SB0 6SB2 6U62
Enriched GO Terms of Interacting Partners?
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