DLEU1 and UBR1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		DLEU1	UBR1
Description		deleted in lymphocytic leukemia 1	ubiquitin protein ligase E3 component n-recognin 1
Image		No pdb structure
GO Annotations	Cellular Component		Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function		Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding
	Biological Process		Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adiponectin levels ( 26299439) Adiponectin levels (BMI-adjusted) ( 26299439) Aluminium levels ( 26025379) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood urea nitrogen levels ( 31152163) Body shape index ( 34021172) Circulating odd-numbered chain saturated fatty acid levels (C19:0) ( 29738550) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) FEV1 ( 30804560) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 31562340 31217584 33713608) Hematocrit ( 29403010 32888494) Hemoglobin ( 29403010 32888494) Hip circumference adjusted for BMI ( 28552196 34021172) Hip index ( 34021172) Lipoprotein (a) levels ( 30108283) Low density lipoprotein cholesterol levels ( 32154731) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21833088 27386562) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Plasma anti-thyroid peroxidase levels ( 29678681) Platelet distribution width ( 32888494) Primary biliary cholangitis ( 26394269) Prostate-specific antigen levels ( 28139693) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tumor necrosis factor alpha levels ( 31217265) Type 2 diabetes ( 30054458 30297969 32499647) Urinary albumin-to-creatinine ratio ( 31630189) Urinary magnesium excretion ( 31993563) Waist-hip index ( 34021172) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172) Weight ( 28552196) White blood cell count ( 32888494)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		20 interacting genes: ABCD4 ABCF3 ARL8B CCDC90B CEP126 COPS6 EEF1A1 EEF1G GDF9 GOPC KAT5 MED31 PSMA1 SETDB1 SHMT1 TLE1 TP53 TUBB4B UBR1 UTP14A	31 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2
Entrez ID		10301	197131
HPRD ID		16150	09342
Ensembl ID		ENSG00000176124	ENSG00000159459
Uniprot IDs			Q8IWV7
PDB IDs			3NY1 5TDC
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?