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CDK9 and UBE2A
Number of citations of the paper that reports this interaction (PubMedID
22592529
)
22
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, enzymatic study)
CDK9
UBE2A
Description
cyclin dependent kinase 9
ubiquitin conjugating enzyme E2 A
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Elongation Factor Complex
Cyclin/CDK Positive Transcription Elongation Factor Complex
Membrane
Mediator Complex
PML Body
Cytoplasmic Ribonucleoprotein Granule
P-TEFb Complex
Chromatin
XY Body
Nucleoplasm
Cytosol
HULC Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Binding
DNA Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Protein Kinase Binding
7SK SnRNA Binding
Protein Serine Kinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
DNA Repair
Regulation Of DNA Repair
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
Protein Phosphorylation
Regulation Of Mitotic Cell Cycle
Cell Population Proliferation
Response To Xenobiotic Stimulus
Positive Regulation Of Cardiac Muscle Hypertrophy
Regulation Of Histone Modification
Replication Fork Processing
Positive Regulation Of Histone Phosphorylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Muscle Cell Differentiation
Regulation Of Cell Cycle
Phosphorylation Of RNA Polymerase II C-terminal Domain
Cellular Response To Cytokine Stimulus
Negative Regulation Of MRNA Polyadenylation
Positive Regulation Of MRNA 3'-UTR Binding
Positive Regulation Of Histone H2B Ubiquitination
Protein Polyubiquitination
Blastocyst Hatching
DNA Repair
Postreplication Repair
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cell Population Proliferation
Response To UV
Histone Ubiquitination
Histone H2A Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Maternal Process Involved In Female Pregnancy
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Pathways
Formation of RNA Pol II elongation complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Interactions of Tat with host cellular proteins
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Alvocidib
Seliciclib
Diseases
GWAS
Body mass index (
26426971
)
Brain connectivity (
23471985
)
Interacting Genes
59 interacting genes:
ACTL6A
AFF4
AR
BCL10
CASK
CCNK
CCNT1
CCNT2
CDC34
CDC7
CDK5R1
CDK7
CEBPB
CTDP1
CTDSPL
CUL1
DHX30
EEF1D
FBXO25
GRN
GTF2F1
H2BC21
HEXIM1
HEXIM2
HLTF
HSPA1A
HTATSF1
IL6ST
LBX2
MBP
MDFIC
MED21
MYBL2
MYC
NBN
NFKB1
NR2E3
OGT
PIN1
POLR2A
RB1
RCHY1
RELA
RMND5B
RN7SK
SERPINH1
SKP1
SKP2
SMAD1
SMAD2
SMAD3
STAT3
STK36
SUPT5H
TAF7
TP53
TRAF2
UBE2A
ZMYM6
26 interacting genes:
CBX5
CDK1
CDK2
CDK9
CDKN2A
CRMP1
EEF1D
H2BC21
HLTF
KCMF1
MDM2
PCNA
PRKN
RAD18
RC3H1
RNF20
RNF4
RNF40
SDCBP
TP53
TRIM27
UBA1
UBR1
UBR3
UBR5
ZMYM2
Entrez ID
1025
7319
HPRD ID
16016
02422
Ensembl ID
ENSG00000136807
ENSG00000077721
Uniprot IDs
A0A024R880
P50750
A0A0D9SG71
P49459
PDB IDs
1PF6
3BLH
3BLQ
3BLR
3LQ5
3MI9
3MIA
3MY1
3TN8
3TNH
3TNI
4BCF
4BCG
4BCH
4BCI
4BCJ
4EC8
4EC9
4IMY
4OGR
4OR5
5L1Z
6CYT
6GZH
6Z45
6CYO
6CYR
Enriched GO Terms of Interacting Partners
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