USPL1 and RANGAP1

Number of citations of the paper that reports this interaction (PubMedID 22878415)
61

Data Source:
BioGRID (enzymatic study)

		USPL1	RANGAP1
Description		ubiquitin specific peptidase like 1	Ran GTPase activating protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cajal Body	Kinetochore Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Aggresome Dendrite Nuclear Membrane Intracellular Membrane-bounded Organelle Nuclear Pore Cytoplasmic Filaments Perinuclear Region Of Cytoplasm Mitotic Spindle Axon Cytoplasm Cytoplasmic Periphery Of The Nuclear Pore Complex
	Molecular Function	Protein Binding SUMO Binding Ubiquitin Binding SUMO-specific Isopeptidase Activity	RNA Binding GTPase Activator Activity Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Cadherin Binding
	Biological Process	Cell Population Proliferation SnRNA Transcription Protein Desumoylation Cajal Body Organization	Signal Transduction Negative Regulation Of Protein Export From Nucleus Response To Axon Injury Activation Of GTPase Activity Cellular Response To Vasopressin
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMO E3 ligases SUMOylate target proteins SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Bitter beverage consumption ( 31046077) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Lamb consumption ( 32066663) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: RANGAP1 SP100 SUMO1 SUMO2 SUMO3 TSC2	23 interacting genes: AXIN2 CCL5 CSNK2A1 DLC1 GNAI1 GNAI3 IPO8 MAP3K8 MUL1 OGT PDGFRL PRKACA PTEN RAN RANBP2 SENP1 SENP2 SUMO1 SUMO2 SUMO3 UBE2E3 UBE2I USPL1
Entrez ID		10208	5905
HPRD ID		09833	03839
Ensembl ID		ENSG00000132952	ENSG00000100401
Uniprot IDs		A8K1B1 B3KQ64 Q5W0Q7	A0A024R1U0 P46060 Q9BSK3
PDB IDs			1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2IO2 2IO3 2IY0 3UIN 3UIO 3UIP 5D2M
Enriched GO Terms of Interacting Partners?
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