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PSME3 and RPH3AL
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
PSME3
RPH3AL
Description
proteasome activator subunit 3
rabphilin 3A like (without C2 domains)
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Activator Complex
Membrane
Cytoplasm
Transport Vesicle Membrane
Secretory Granule Membrane
Molecular Function
P53 Binding
Protein Binding
Identical Protein Binding
Endopeptidase Activator Activity
MDM2/MDM4 Family Protein Binding
Protein Binding
Cytoskeletal Protein Binding
LIM Domain Binding
Small GTPase Binding
Metal Ion Binding
Biological Process
Apoptotic Process
Cell Cycle
Positive Regulation Of Endopeptidase Activity
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Intracellular Protein Transport
Exocytosis
Response To Xenobiotic Stimulus
Regulation Of Exocytosis
Positive Regulation Of Protein Secretion
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
AIDS progression (
21502085
)
Dimensional psychopathology (Cognitive) (
29496196
)
Idiopathic intracranial hypertension (
29608535
)
Impaired insulin sensitivity in response to n-3 PUFA supplementation (
31779001
)
Interacting Genes
68 interacting genes:
ABCF3
ADAP1
AICDA
ATN1
ATP5F1B
BBS2
CASP3
CASP6
CASP7
CDC25B
CDC42
CDR2L
CHEK2
COIL
CREBBP
DEPTOR
DIP2A
DMRT3
DTNBP1
DVL3
EAF1
EAF2
FAM90A1
FBXL12
FMR1
FOXD4L1
FXR1
FXR2
GPATCH2L
HDAC5
HSPA5
IKZF3
INPP5J
ITPKB
KANSL1
KBTBD7
KLF2
LNX1
MDM2
MEOX2
NCOA3
NTAQ1
NUDT18
PFDN5
PIAS1
PICK1
PKD1L1
PRKAB2
PRR13
RDX
RNF111
RPH3AL
RPS27
SERF2
SIRT1
SMURF1
SPG7
TBP
TBXA2R
THAP10
TNFAIP8L1
TP53
TXN2
UBE2H
UBE2I
WDR25
YWHAQ
ZCCHC10
25 interacting genes:
ANKRD11
ATPAF2
C1orf109
HNRNPK
KHDRBS3
MID2
MYO15B
PNMA3
PRKAB2
PSME3
RAB27A
RAB27B
RAB3A
RAB3B
RAB3C
RAB3D
RAB3GAP1
RAB8A
RIMS2
RSPH14
SAAL1
SCNM1
TCEA3
UNC13B
ZYX
Entrez ID
10197
9501
HPRD ID
05500
05345
Ensembl ID
ENSG00000131467
ENSG00000181031
Uniprot IDs
A0A024R203
B3KQ25
P61289
Q6MZZ1
V9HWJ8
A8K7D5
Q9UNE2
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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