MEI4 and POLR1C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MEI4	POLR1C
Description		meiotic double-stranded break formation protein 4	RNA polymerase I and III subunit C
Image		No pdb structure
GO Annotations	Cellular Component	Lateral Element	Nucleoplasm RNA Polymerase III Complex RNA Polymerase I Complex Cytosol
	Molecular Function	Protein Binding	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	DNA Recombination Homologous Chromosome Pairing At Meiosis Spermatogenesis Meiotic DNA Double-strand Break Formation Oogenesis	Transcription By RNA Polymerase I Transcription By RNA Polymerase III
Pathways			Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS		Brain volume in infants (white matter) ( 28763065) Cadmium levels ( 26025379) Daytime nap ( 33568662) HDL cholesterol levels in HIV infection ( 33109212) Macular thickness ( 30535121)	GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		36 interacting genes: AFMID BAG4 C19orf25 C1orf109 CABP5 CDKN2D CHAF1A CPNE2 CST9L CTTNBP2 DNTT EIF5A FKBP6 GRB2 HSD3B7 IQGAP1 LGALS14 MACO1 METTL21A MLX MTMR9 MYO5B NGB NME7 OSGIN1 PAFAH1B3 PHYHIPL PLEKHA4 POLR1C R3HDM2 TRAPPC2L TRIM59 TSEN15 TSSK3 USHBP1 VPS26C	118 interacting genes: ADAMTSL4 ARHGEF5 ATRIP AVPI1 BHLHB9 BIN3 BIRC7 BLZF1 C1orf105 C21orf58 C4orf45 CBX8 CBY2 CCDC33 CCNK CCT3 CGGBP1 CLU CORO1A CORO1B CRACR2A EFHC2 EP400 FH FMR1 FOXR2 GAS8 GMPPB GOLGA6A GOLGA6L9 GRPEL1 GSTO2 HDX HNRNPH1 HOXB9 HOXD12 IHO1 IKZF3 INCA1 KCTD1 KCTD13 KLF15 KRT19 KRT75 KRT76 KRTAP12-2 KRTAP3-1 LNX2 LRIF1 LZTS1 LZTS2 MBIP MEI4 MEOX2 MKRN3 MORN3 MRPS23 MYD88 MYO5B NDUFB10 NEDD4 NFKBIB NIF3L1 NME1 NME4 PIH1D2 POLDIP3 POLR1D POLR1E POLR1G POLR2G POLR2J3 PPP2R3C PSMA1 RBM48 RIMBP3 RIMBP3C RSPH14 RUSC1 SAXO1 SMN1 SMN2 SORBS3 SPATC1L SPRY1 STMN3 TASOR2 TAX1BP1 TCF4 TEX43 TFIP11 TLE5 TMEM121 TNFAIP1 TNNI1 TRAIP TRIM14 TRIM27 TRIOBP TSC22D4 UNKL USP54 VIM WASHC1 WRN XPA YPEL3 ZBED1 ZBTB42 ZC2HC1C ZFP57 ZIM2 ZNF547 ZNF554 ZNF655 ZNF688 ZNF835 ZRANB1
Entrez ID		101928601	9533
HPRD ID			09661
Ensembl ID		ENSG00000269964	ENSG00000171453
Uniprot IDs		A8MW99	O15160
PDB IDs			7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59
Enriched GO Terms of Interacting Partners?
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