RASGRP1 and AQR

		RASGRP1	AQR
Description		RAS guanyl releasing protein 1	aquarius intron-binding spliceosomal factor
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding Phosphatidylcholine Binding Identical Protein Binding	RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity 3'-5' RNA Helicase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Inflammatory Response To Antigenic Stimulus Signal Transduction Ras Protein Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Signaling Natural Killer Cell Activation Cell Differentiation Secretory Granule Localization Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus T Cell Proliferation B Cell Proliferation T Cell Activation B Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of JNK Cascade Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Regulation Of Phospholipase C Activity Regulation Of P38MAPK Cascade	MRNA Splicing, Via Spliceosome
Pathways		Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Bipolar disorder ( 18711365) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Crohn's disease ( 28067908 23128233) Estimated glomerular filtration rate ( 30604766) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Multiple sclerosis ( 24076602) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Psychosis (atypical) ( 24132900) Rheumatoid arthritis ( 32723749 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 33272962 28714469) Type 1 diabetes ( 21829393 25751624 18840781) Type 2 diabetes ( 30297969 28254843 22961080 32499647 30718926)
Interacting Genes		9 interacting genes: AQR CD19 DAP DGKZ DNAH8 HRAS MAPK7 MGA TRIM33	42 interacting genes: CHRNA7 MIR1-1 MIR106A MIR106B MIR107 MIR128-2 MIR145 MIR15B MIR199A2 MIR19B1 MIR19B2 MIR200B MIR200C MIR205 MIR206 MIR20B MIR214 MIR221 MIR222 MIR25 MIR29A MIR31 MIR34A MIR34B MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7G MIRLET7I PQBP1 RASGRP1 RBM22 RBM4 WDR77
Entrez ID		10125	9716
HPRD ID		04909	12468
Ensembl ID		ENSG00000172575	ENSG00000021776
Uniprot IDs		B2RA89 O95267	A0A024R9L1 O60306
PDB IDs		4L9M 4L9U	4PJ3 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7ABI
Enriched GO Terms of Interacting Partners?
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