SH2D3C and SNCAIP

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SH2D3C	SNCAIP
Description		SH2 domain containing 3C	synuclein alpha interacting protein
Image
GO Annotations	Cellular Component	Cytoplasm Axon Ruffle Membrane	Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Neuronal Cell Body
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity	Cell Death Dopamine Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly
Pathways			Amyloid fiber formation
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494)	Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes ( 31537649) Delirium ( 29631748) Depressive symptoms x independent stressful life events interaction (2df test) ( 30718454) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mood disorder and prion disease ( 25897833) Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50) ( 27047539)
Interacting Genes		17 interacting genes: AR BCAR1 CARD11 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 GOLGA2 KIT MAPK1 MET NEDD9 PTK2B SNCAIP SRC	19 interacting genes: AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PIN1 PINK1 PPHLN1 PRKN PTN RNF19A SEPTIN4 SH2D3C SIAH1 SIAH2 SNCA TLE5 UBB
Entrez ID		10044	9627
HPRD ID		05284	04804
Ensembl ID		ENSG00000095370	ENSG00000064692
Uniprot IDs		B4DG32 Q8N5H7	B7Z616 B7Z995 Q6L981 Q6L983 Q9Y6H5
PDB IDs		3T6G	2KES
Enriched GO Terms of Interacting Partners?
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