ABI1 and SPTAN1

Number of citations of the paper that reports this interaction (PubMedID 9593709)
38

Data Source:
HPRD (two hybrid, in vitro)

		ABI1	SPTAN1
Description		abl interactor 1	spectrin alpha, non-erythrocytic 1
Image		No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Endoplasmic Reticulum Cytosol Cytoskeleton Postsynaptic Density Lamellipodium Growth Cone SCAR Complex Filopodium Tip Extracellular Exosome	Extracellular Region Cytosol Plasma Membrane Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen
	Molecular Function	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity Cadherin Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Somitogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation Megakaryocyte Development Dendrite Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis	Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament Capping
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS			Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		69 interacting genes: ABI2 ABL1 APBB1 C22orf15 CACNA1A CCDC57 CCHCR1 CUL2 CYFIP2 DST DTNB EIF3H ENAH ENKD1 EPS8 EPS8L1 EVL FAM124B FBXL19 FHL2 FXR1 GAS7 HHEX HNRNPK HOMER1 HOMER3 HSPA8 KIAA0408 KIAA1217 KTN1 LMO1 MAB21L2 MINK1 MRFAP1 MRFAP1L1 NCK1 NCK2 NCKAP1 NEB NFASC NHSL2 NIN OGT PAK2 PCM1 PRKAA2 PRPF40A RBM15 RCOR3 SHANK3 SMARCD1 SORBS1 SORBS2 SOS1 SOS2 SPTA1 SPTAN1 SRP68 SRRM1 SYNE2 TCERG1 TLN1 TRIP10 TSC1 TTC23 VARS2 VASP WASF1 WASF2	60 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 C5 CAPN1 CASP3 CASP7 CEP63 CNTRL CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D KALRN KARS1 MAPK6 NEFL PDE4D PIN4 PLEC PLEKHA5 PRKCB PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN2 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TRAF1 TSSC4 ZNF333
Entrez ID		10006	6709
HPRD ID		04336	01684
Ensembl ID		ENSG00000136754	ENSG00000197694
Uniprot IDs		A0A0A0MRT6 B6VEX3 B6VEX4 B6VEX5 Q8IZP0	A0A384P5S9 Q13813
PDB IDs			2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
Enriched GO Terms of Interacting Partners?
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