TAP2

Description		transporter 2, ATP binding cassette subfamily B member
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Speck Integral Component Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex TAP Complex
	Molecular Function	Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase-coupled Transmembrane Transporter Activity Metal Ion Binding TAP1 Binding Tapasin Binding Peptide Transmembrane Transporter Activity
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Peptide Antigen Transport Transmembrane Transport
Pathways		ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Lymphocyte counts ( 32888494) Lymphoma ( 23349640) Nephropathy ( 21399633) Platelet distribution width ( 32888494) Pubertal anthropometrics ( 23449627) Response to hepatitis B vaccine ( 29534301) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP
Entrez ID		6891
HPRD ID		01360
Ensembl ID		ENSG00000204267
Uniprot IDs		Q03519 Q5JNW1 Q9UP03 X5CMH5
PDB IDs		5U1D
Enriched GO Terms of Interacting Partners?
Tagcloud ?