CUL3 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	AGFG1	ArfGAP with FG repeats 1	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Novel	FAM124B	family with sequence similarity 124 member B
Novel	GYPA	glycophorin A (MNS blood group)	Cell surface interactions at the vascular wall
Novel	NDUFA10	NADH:ubiquinone oxidoreductase subunit A10	Respiratory electron transport Complex I biogenesis	NADH
Novel	SRA1	steroid receptor RNA activator 1
Novel	ZAP70	zeta chain of T cell receptor associated protein kinase 70	Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules	Staurosporine Fostamatinib	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
	ABTB1	ankyrin repeat and BTB domain containing 1
	ABTB2	ankyrin repeat and BTB domain containing 2
	ACLY	ATP citrate lyase	ChREBP activates metabolic gene expression Neutrophil degranulation Fatty acyl-CoA biosynthesis	Bempedoic acid
	APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form	Alzheimer's disease (AD)
	ARHGEF12	Rho guanine nucleotide exchange factor 12	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse
	BTBD1	BTB domain containing 1	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
	BTBD10	BTB domain containing 10
	BTBD2	BTB domain containing 2
	BTBD3	BTB domain containing 3
	BTBD6	BTB domain containing 6	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
	CAMK1D	calcium/calmodulin dependent protein kinase ID		N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE Fostamatinib
	CAND1	cullin associated and neddylation dissociated 1	Neutrophil degranulation Neddylation Iron uptake and transport
	CCND1	cyclin D1	SCF(Skp2)-mediated degradation of p27/p21 Pre-NOTCH Transcription and Translation RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Acetylsalicylic acid Arsenic trioxide Encorafenib Bryostatin 1	Hairy-cell leukemia von Hippel-Lindau syndrome Esophageal cancer Oral cancer Multiple myeloma Laryngeal cancer Breast cancer
	CCNE1	cyclin E1	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) RHOBTB3 ATPase cycle		Laryngeal cancer Gastric cancer

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