PRKAR2A - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
AKAP8	A-kinase anchoring protein 8
AKAP9	A-kinase anchoring protein 9	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
ARFGEF2	ADP ribosylation factor guanine nucleotide exchange factor 2	Association of TriC/CCT with target proteins during biosynthesis		Periventricular nodular heterotopia (PVNH)
CBFA2T3	CBFA2/RUNX1 partner transcriptional co-repressor 3
CFTR	CF transmembrane conductance regulator	ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	ATP Bumetanide Glyburide Ibuprofen Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor	Cystic fibrosis (CF) Hereditary pancreatitis; Hereditary chronic pancreatitis Congenital bilateral absence of vas deferens
EZR	ezrin	Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1
FOS	Fos proto-oncogene, AP-1 transcription factor subunit	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Pseudoephedrine Nadroparin
LRIF1	ligand dependent nuclear receptor interacting factor 1
MAP2	microtubule associated protein 2		Estramustine Paclitaxel Docetaxel
MYCBPAP	MYCBP associated protein
NBEA	neurobeachin	Neurotransmitter receptors and postsynaptic signal transmission PKA activation NOTCH1 Intracellular Domain Regulates Transcription Assembly and cell surface presentation of NMDA receptors
PJA2	praja ring finger ubiquitin ligase 2	Antigen processing: Ubiquitination & Proteasome degradation
PPP1CB	protein phosphatase 1 catalytic subunit beta	Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition Circadian Clock RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation Signaling by MRAS-complex mutants
PRKX	protein kinase X-linked	PKA-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of Adenylate Cyclase ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
RAB32	RAB32, member RAS oncogene family	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
RET	ret proto-oncogene	RAF/MAP kinase cascade RET signaling	Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Lenvatinib Fostamatinib Amuvatinib Selpercatinib Pralsetinib	Hirschsprung disease (HD) Renal agenesis and Renal adysplasia Thyroid cancer Congenital central hypoventilation syndrome (CCHS)
RUNX1T1	RUNX1 partner transcriptional co-repressor 1			Acute myeloid leukemia (AML)
RYR2	ryanodine receptor 2	Stimuli-sensing channels Ion homeostasis	Flecainide Tetracaine	Arrhythmogenic right ventricular cardiomyopathy (ARVC) Catecholaminergic polymorphic ventricular tachycardia
SCTR	secretin receptor	G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Secretin human
SEMG2	semenogelin 2		Zinc chloride Zinc sulfate, unspecified form

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