PRKAR2A and MAP2

Data Source:
HPRD (in vivo)

		PRKAR2A	MAP2
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	microtubule associated protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Cytoplasm Cytosol Microtubule Microtubule Associated Complex Dendrite Dendrite Cytoplasm Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Axon Hillock Dendritic Growth Cone Main Axon Dendritic Branch Basal Dendrite Primary Dendrite Distal Dendrite Apical Distal Dendrite Dendritic Filopodium Proximal Dendrite Proximal Neuron Projection
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Dystroglycan Binding Structural Molecule Activity Protein Binding Calmodulin Binding Microtubule Binding Tau Protein Binding
	Biological Process	Renal Water Homeostasis Blood Coagulation Regulation Of Protein Kinase A Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Regulation Of CAMP-mediated Signaling Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Dendrite Development Central Nervous System Neuron Development Negative Regulation Of Axon Extension Regulation Of Microtubule Polymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Dendrite Morphogenesis Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Anterograde Synaptic Vesicle Transport Regulation Of Cellular Protein Localization Negative Regulation Of Microtubule Binding Negative Regulation Of Microtubule Motor Activity
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs		GEM-231	Estramustine Paclitaxel Docetaxel
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Heel bone mineral density ( 30598549) Height ( 31562340) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Adventurousness ( 30643258) Bipolar disorder ( 31043756) Body mass index ( 28552196) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Handedness (Left-handed vs. non-left-handed) ( 31504236 30980028) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 28552196) Left-handedness ( 32989287) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		34 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CFTR EZR FOS LRIF1 MAP2 MYCBPAP NBEA PJA2 PPP1CB PRKX RAB32 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1	25 interacting genes: ACTB ACTN1 APOE APP CPEB1 DAG1 FYN GRB2 GRIN1 GRIN2D JUNB MARK1 MARK3 MARK4 MDM2 MYO7A NEDD4L NEFL PAFAH1B1 PLEC PRKACA PRKAR2A SRC TTBK1 TUBA1A
Entrez ID		5576	4133
HPRD ID		01484	01140
Ensembl ID		ENSG00000114302	ENSG00000078018
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A8KAH7 P13861	A0A024R3Y8 A0A024R3Z1 A0A024R409 P11137 Q6NYC5
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY
Enriched GO Terms of Interacting Partners?
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