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ICOS |
inducible T cell costimulator |
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- Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
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TNF |
tumor necrosis factor |
- Transcriptional regulation of white adipocyte differentiation
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- TNFR1-mediated ceramide production
- TNFR2 non-canonical NF-kB pathway
- Interleukin-10 signaling
- Interleukin-4 and Interleukin-13 signaling
- TNF signaling
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- Etanercept
- Adalimumab
- Infliximab
- Chloroquine
- Epinephrine
- Pseudoephedrine
- Thalidomide
- Glucosamine
- Clenbuterol
- Pranlukast
- Amrinone
- Afelimomab
- YSIL6
- SD118
- PN0621
- OMS-103HP
- Talmapimod
- VX-702
- Atiprimod
- CRx-139
- CYT007-TNFQb
- Andrographolide
- Ethyl pyruvate
- AME-527
- PR-104
- Plinabulin
- Dexanabinol
- Onercept
- Golimumab
- Certolizumab pegol
- Pomalidomide
- Polaprezinc
- Foreskin fibroblast (neonatal)
- Foreskin keratinocyte (neonatal)
- Bryostatin 1
- Binimetinib
- Dilmapimod
- Glycyrrhizic acid
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- Graft-versus-host disease
- Asthma
- Allograft rejection
- Systemic lupus erythematosus
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TNFRSF4 |
TNF receptor superfamily member 4 |
- TNFs bind their physiological receptors
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UBE2A |
ubiquitin conjugating enzyme E2 A |
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2B |
ubiquitin conjugating enzyme E2 B |
- Recognition of DNA damage by PCNA-containing replication complex
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2D2 |
ubiquitin conjugating enzyme E2 D2 |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- TICAM1, RIP1-mediated IKK complex recruitment
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- CLEC7A (Dectin-1) signaling
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Neddylation
- Peroxisomal protein import
- Negative regulators of DDX58/IFIH1 signaling
- IKK complex recruitment mediated by RIP1
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2F |
ubiquitin conjugating enzyme E2 F (putative) |
- Neddylation
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2G1 |
ubiquitin conjugating enzyme E2 G1 |
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2G2 |
ubiquitin conjugating enzyme E2 G2 |
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2L3 |
ubiquitin conjugating enzyme E2 L3 |
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2N |
ubiquitin conjugating enzyme E2 N |
- ISG15 antiviral mechanism
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- CLEC7A (Dectin-1) signaling
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- G2/M DNA damage checkpoint
- E3 ubiquitin ligases ubiquitinate target proteins
- Interleukin-1 signaling
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- Aggrephagy
- Aggrephagy
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2V1 |
ubiquitin conjugating enzyme E2 V1 |
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- CLEC7A (Dectin-1) signaling
- Interleukin-1 signaling
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- Aggrephagy
- Aggrephagy
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2V2 |
ubiquitin conjugating enzyme E2 V2 |
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- G2/M DNA damage checkpoint
- E3 ubiquitin ligases ubiquitinate target proteins
- Antigen processing: Ubiquitination & Proteasome degradation
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UCP3 |
uncoupling protein 3 |
- The fatty acid cycling model
- The proton buffering model
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