RC3H1 and ICOS

Data Source:
BioGRID (unspecified method)

		RC3H1	ICOS
Description		ring finger and CCCH-type domains 1	inducible T cell costimulator
Image
GO Annotations	Cellular Component	P-body Cytoplasmic Stress Granule	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding MiRNA Binding RNA Stem-loop Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process B Cell Homeostasis Regulation Of Germinal Center Formation Negative Regulation Of Germinal Center Formation Ubiquitin-dependent Protein Catabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation P-body Assembly T Cell Proliferation T Cell Homeostasis Regulation Of MRNA Stability Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization T Follicular Helper Cell Differentiation Cellular Response To Interleukin-1 Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process	T Cell Tolerance Induction Immune Response T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Cell-cell Adhesion
Pathways
Drugs
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS			Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)
Interacting Genes		14 interacting genes: ICOS TNF TNFRSF4 UBE2A UBE2B UBE2D2 UBE2F UBE2G1 UBE2G2 UBE2L3 UBE2N UBE2V1 UBE2V2 UCP3	4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1
Entrez ID		149041	29851
HPRD ID		13913	09196
Ensembl ID		ENSG00000135870	ENSG00000163600
Uniprot IDs		B7ZMB3 B9EGU6 Q5TC82	Q53QY6 Q9Y6W8
PDB IDs		3X1O 4QIK 4QIL 4ULW 4YWQ	6X4G 7JOO
Enriched GO Terms of Interacting Partners?
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