JOSD1 and PJA1

Data Source:
BioGRID (enzymatic study)

		JOSD1	PJA1
Description		Josephin domain containing 1	praja ring finger ubiquitin ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Cytoplasm
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation	Protein Ubiquitination Protein Catabolic Process
Pathways		Josephin domain DUBs	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Plateletcrit ( 32888494) Resting heart rate ( 27798624) Sleep duration ( 30846698)	Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		38 interacting genes: ADAMTSL4 CARD10 CYSRT1 FBLN2 KRT27 KRT31 KRT34 KRT40 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-4 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 KRTAP9-2 KRTAP9-3 LNX1 MDFI MID2 MTUS2 NBPF19 NOTCH2NLA PJA1 STUB1 TGM1 TRAF1 TRIM23 TRIM27 TRIM54 TRIM63 UBC USP15 USP21 USP28	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		9929	64219
HPRD ID		08823	02335
Ensembl ID		ENSG00000100221	ENSG00000181191
Uniprot IDs		A0A024R1P5 Q15040	Q8NG27
PDB IDs			2L0B
Enriched GO Terms of Interacting Partners?
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