SRGAP3 and SMARCC2

Data Source:
HPRD (in vivo)

		SRGAP3	SMARCC2
Description		SLIT-ROBO Rho GTPase activating protein 3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleoplasm SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex
	Molecular Function	GTPase Activator Activity Protein Binding	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways		Rho GTPase cycle Inactivation of CDC42 and RAC1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Body fat percentage ( 31752434) Lead levels in blood ( 25820613) Rapid automised naming of letters ( 30741946)	Asthma ( 31619474) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: DISC1 DTNBP1 ENKD1 FASLG KDM1A PRMT6 RAC1 SMARCC2 SUV39H1 TNIK WASF1	26 interacting genes: ARRB2 ATXN1 ATXN1L BAZ1B CSNK2A1 EWSR1 FUS GATA1 IFTAP ITCH ITSN1 KLF1 KRT27 MCPH1 NOVA1 PEX14 PHYHIP POLR2C RAB1B RELB SMARCB1 SP1 SRGAP3 TAF15 TERF1 TERF2IP
Entrez ID		9901	6601
HPRD ID		12108	03437
Ensembl ID		ENSG00000196220	ENSG00000139613
Uniprot IDs		O43295	A0A024RB22 F8VXC8 Q8TAQ2
PDB IDs			6KAG 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?
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