SV2A and VPS45

Data Source:
BioGRID (affinity chromatography technology)

		SV2A	VPS45
Description		synaptic vesicle glycoprotein 2A	vacuolar protein sorting 45 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Synaptic Vesicle Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane Dendrite Synaptic Vesicle Membrane Neuromuscular Junction Neuron Projection Neuronal Cell Body Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse	Golgi Membrane Cellular_component Golgi Apparatus Endosome Membrane Integral Component Of Membrane
	Molecular Function	Protein Kinase Binding Transmembrane Transporter Activity	Molecular_function Protein Binding
	Biological Process	Cellular Calcium Ion Homeostasis Regulation Of Gamma-aminobutyric Acid Secretion Synaptic Vesicle Priming Transmembrane Transport	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Blood Coagulation Vesicle-mediated Transport
Pathways		Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type F (botF) Toxicity of botulinum toxin type E (botE)	Intra-Golgi traffic Factors involved in megakaryocyte development and platelet production
Drugs		Levetiracetam Brivaracetam Seletracetam
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Height ( 25429064 31562340 18391951) Lung function (FEV1) ( 26635082)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Obesity in adult survivors of childhood cancer not exposed to cranial radiation ( 25963547) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Uric acid levels ( 21294900)
Interacting Genes		4 interacting genes: ATXN1 DNAJC5 LAMA5 LTB4R2	11 interacting genes: BCAR3 CASP8 IGF1R PAX2 PTPN1 RB1CC1 RBSN SNTG1 STX16 VPS11 VPS18
Entrez ID		9900	11311
HPRD ID		08922	10301
Ensembl ID		ENSG00000159164	ENSG00000136631
Uniprot IDs		B4E000 Q7L0J3	A0A2R8YE10 B7Z360 B7Z5D4 Q9NRW7
PDB IDs		4V11
Enriched GO Terms of Interacting Partners?
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