SEPTIN7 and CENPE

Data Source:
BioGRID (two hybrid)

		SEPTIN7	CENPE
Description		septin 7	centromere protein E
Image
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Stress Fiber Nucleus Spindle Cytosol Axoneme Septin Ring Microtubule Cytoskeleton Apical Plasma Membrane Midbody Septin Complex Cell Division Site Cleavage Furrow Extracellular Exosome Sperm Annulus Non-motile Cilium	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Kinetochore Microtubule Cytosol Microtubule Microtubule Cytoskeleton Membrane Midbody Spindle Midzone Mitotic Spindle Midzone
	Molecular Function	GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Cadherin Binding Molecular Adaptor Activity	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed Kinetochore Binding
	Biological Process	Spermatogenesis Regulation Of Embryonic Cell Shape Cell Differentiation Cellular Protein Localization Cilium Assembly Cytoskeleton-dependent Cytokinesis Positive Regulation Of Non-motile Cilium Assembly	Mitotic Cell Cycle Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Mitotic Spindle Organization Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Multicellular Organism Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways		MAPK6/MAPK4 signaling	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins
Drugs			GSK-923295
Diseases
GWAS			Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Schizophrenia ( 28991256) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Testicular germ cell tumor ( 25877299 28604728 28604732 23666240)
Interacting Genes		13 interacting genes: ANLN CDC42EP2 CDC42EP3 CDC42EP5 CENPE HDAC6 LINC01554 REL S100A4 SEPTIN10 SEPTIN11 SEPTIN5 SEPTIN9	12 interacting genes: BUB1B CENPF CLK1 CUL1 DNAJB1 DUX1 FANCA NUF2 SEPTIN7 SKP1 TRAF4 UBC
Entrez ID		989	1062
HPRD ID		04398	00316
Ensembl ID		ENSG00000122545	ENSG00000138778
Uniprot IDs		A0A023T695 A8K3D0 B4DNE4 G3V1Q4 Q16181	Q02224
PDB IDs		2QAG 3T5D 3TW4 6N0B 6N12 6UQQ	1T5C 5JVP
Enriched GO Terms of Interacting Partners?
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