TLK1 and TLK2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TLK1	TLK2
Description		tousled like kinase 1	tousled like kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation
Pathways
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		Health literacy ( 31250787) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 32888494 27863252)	Heel bone mineral density ( 30598549) Lifespan ( 25918517)
Interacting Genes		28 interacting genes: ASF1A ASF1B AURKA BEND7 BHLHB9 CHEK1 DPPA4 DYNLL2 H1-1 LHX2 LUZP4 MBP NBN PAX6 PINX1 PTPN11 RAD9A SNAP23 TFCP2 TLK2 TPM3 UBE3C YAF2 YWHAE ZNF655 ZNF773 ZNF829 ZSCAN22	17 interacting genes: ASF1A ASF1B AURKA CEP70 DMAP1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ
Entrez ID		9874	11011
HPRD ID		12232	10527
Ensembl ID		ENSG00000198586	ENSG00000146872
Uniprot IDs		Q9UKI8	B4DUC2 J3QLK5 Q86UE8
PDB IDs			5O0Y
Enriched GO Terms of Interacting Partners?
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