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SETDB1 and TOB1
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
SETDB1
TOB1
Description
SET domain bifurcated histone lysine methyltransferase 1
transducer of ERBB2, 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Intracellular Membrane-bounded Organelle
Nucleus
Cytoplasm
CCR4-NOT Complex
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Zinc Ion Binding
Histone-lysine N-methyltransferase Activity
Histone Methyltransferase Activity (H3-K9 Specific)
Promoter-specific Chromatin Binding
Transcription Corepressor Activity
Protein Binding
Receptor Tyrosine Kinase Binding
SMAD Binding
Biological Process
Ras Protein Signal Transduction
Negative Regulation Of Gene Expression
Response To Vitamin
Response To Ethanol
Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Histone H3-K9 Methylation
Heterochromatin Organization
Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly
Negative Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
Negative Regulation Of Translation
Negative Regulation Of BMP Signaling Pathway
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways
PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Body mass index (
26426971
)
Chronic kidney disease (
20383146
)
Coffee consumption (
31046077
)
Cutaneous squamous cell carcinoma (
32041948
)
Melanoma (
21983785
)
Neurological blood protein biomarker levels (
31320639
)
Nevus count or cutaneous melanoma (
30429480
)
Blood protein levels (
28240269
)
Interacting Genes
109 interacting genes:
AIFM1
AKT1
ANXA7
APC
APLP1
ASAH1
ATF7IP
ATF7IP2
BAG6
BARD1
BHLHE40
BID
BRIX1
BTBD2
C11orf1
CBX8
CCDC106
CDK4
CDKN1A
CLSTN1
CREBBP
CRELD1
DAP
DLEU1
DNMT3A
ECSIT
ERG
ERH
FAM118B
FLYWCH1
GIPC2
GPS2
GRB7
GSTO1
H3-4
H3C1
H3C15
H4-16
HDAC1
HDAC2
HMOX2
HSF2BP
HSPB3
JARID2
KDM1A
LRIF1
LUC7L2
MAD2L1BP
MAP4K5
MBD1
MDM2
MOB4
MRPL44
MZT2B
NIPSNAP3A
OLFML3
ORAI2
PABPC4
PAFAH1B3
PCDHA4
PCYT2
PGAM5
PHF10
PIAS4
PLEKHA4
POLA2
PPA1
PPP1R8
PRKRA
PSMD11
PSME1
PTPRS
QTRT1
RIF1
RNF10
S100A10
SAT1
SERPINB9
SIN3A
SIN3B
SKIL
SLC38A3
SMN1
SNIP1
SUFU
SULT1E1
SUMO2
TARDBP
TCERG1
THAP8
TK1
TOB1
TOLLIP
TPI1
TRBV2
TRDMT1
TRIB3
TRIM16
TRIM28
TRIP6
TSC22D1
TTR
TXNDC9
UBE2I
ULK2
USP11
VIM
ZFP64
ZNF24
19 interacting genes:
APP
CDC7
CNOT7
CORO7
DTL
ERBB2
MAPK1
MAPK9
MARCKS
PABPC1
SCMH1
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMAD9
Entrez ID
9869
10140
HPRD ID
06828
09273
Ensembl ID
ENSG00000143379
ENSG00000141232
Uniprot IDs
Q15047
P50616
PDB IDs
3DLM
4X3S
5KCH
5KCO
5KE2
5KE3
5KH6
5QT1
5QT2
6AU2
6AU3
6BHD
6BHE
6BHG
6BHH
6BHI
6BPI
2D5R
2Z15
5CI8
5CI9
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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