IST1 and APEH

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		IST1	APEH
Description		IST1 factor associated with ESCRT-III	acylaminoacyl-peptide hydrolase
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Region Nuclear Envelope Endoplasmic Reticulum-Golgi Intermediate Compartment Centrosome Cytosol Midbody Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Flemming Body	Extracellular Region Cytosol Nuclear Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein-containing Complex Binding Cadherin Binding MIT Domain Binding	RNA Binding Serine-type Endopeptidase Activity Protein Binding Omega Peptidase Activity Identical Protein Binding
	Biological Process	Protein Localization Abscission Protein Transport Viral Release From Host Cell Multivesicular Body Assembly Neutrophil Degranulation Establishment Of Protein Localization Positive Regulation Of Proteolysis Viral Capsid Secondary Envelopment Positive Regulation Of Collateral Sprouting Cell Division Cytoskeleton-dependent Cytokinesis ESCRT III Complex Disassembly	Translational Termination Proteolysis Neutrophil Degranulation Amyloid-beta Metabolic Process
Pathways		Neutrophil degranulation Sealing of the nuclear envelope (NE) by ESCRT-III	Neutrophil degranulation Eukaryotic Translation Termination
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 28240269) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) Feeling tense ( 29500382) Feeling worry ( 29500382) Household income ( 31844048) Inflammatory bowel disease ( 28067908) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		9 interacting genes: APEH ATXN1 BAG4 CAPN7 CHMP1A SPAST TOX3 UBQLN1 UBQLN2	5 interacting genes: IST1 LGALS8 SHBG TMEM62 UBA5
Entrez ID		9798	327
HPRD ID		13784	00034
Ensembl ID		ENSG00000182149	ENSG00000164062
Uniprot IDs		B4DXC9 P53990	P13798
PDB IDs		3FRR 3FRS 3JC1 4U7E 4U7I 4U7Y 4WZX 6E8G 6TZ4 6TZ5 6TZA
Enriched GO Terms of Interacting Partners?
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