AQR and MIR221

Data Source:
BioGRID (unspecified method)

		AQR	MIR221
Description		aquarius intron-binding spliceosomal factor	microRNA 221
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Extracellular Space Extracellular Vesicle
	Molecular Function	RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding ATP Binding 3'-5' RNA Helicase Activity	MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair	Negative Regulation Of Cell Population Proliferation Response To Glucose Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Interleukin-21 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation By Host Of Viral Genome Replication Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Regeneration Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Necroptotic Process Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Schwann Cell Migration Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Negative Regulation Of Double-strand Break Repair
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Interacting Genes		40 interacting genes: MIR1-1 MIR106A MIR106B MIR107 MIR128-2 MIR145 MIR15B MIR199A2 MIR19B1 MIR19B2 MIR200B MIR200C MIR205 MIR206 MIR20B MIR214 MIR221 MIR222 MIR25 MIR29A MIR31 MIR34A MIR34B MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7G MIRLET7I PQBP1 RBM22 RBM4 WDR77	87 interacting genes: ADARB1 AIMP2 APOBEC3B AQR C1QBP CELF1 CPSF1 DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FIP1L1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT21 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM2 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346
Entrez ID		9716	407006
HPRD ID		12468
Ensembl ID		ENSG00000021776	ENSG00000207870
Uniprot IDs		A0A024R9L1 O60306
PDB IDs		4PJ3 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P
Enriched GO Terms of Interacting Partners?
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