RNF7 and PLA2G15

Data Source:
HPRD (two hybrid, in vivo)

		RNF7	PLA2G15
Description		ring finger protein 7	phospholipase A2 group XV
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex	Extracellular Region Extracellular Space Nucleoplasm Lysosome Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Copper Ion Binding Protein Binding Zinc Ion Binding NEDD8 Transferase Activity Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding	Lysophospholipase Activity Triglyceride Lipase Activity Phospholipid Binding Zinc Ion Binding O-acyltransferase Activity Phospholipase A1 Activity Acylglycerol O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Phosphatidyl Phospholipase B Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Phosphopantetheinylation Post-translational Protein Modification Protein Neddylation Response To Redox State	Lipid Metabolic Process Phospholipid Metabolic Process Glycerophospholipid Metabolic Process Diacylglycerol Biosynthetic Process Phosphatidylserine Metabolic Process Ceramide Metabolic Process Fatty Acid Catabolic Process Phosphatidylcholine Catabolic Process Phosphatidylethanolamine Catabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Hydrolysis of LPC
Drugs
Diseases
GWAS		Hepatitis C induced liver fibrosis ( 22841784) Pelvic organ prolapse (moderate/severe) ( 26545240)	Body size at age 10 ( 32376654) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		43 interacting genes: APOBEC3F APOBEC3G ASB11 BTRC CASP7 CBFB CDC34 CHFR CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CYCS ELOB ELOC ERBIN GEM GHR GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L PLA2G15 PMAIP1 SOCS3 TRIM46 TRIM8 UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2F UBE2L3 UBE2M UBE2Q1 UBE2S	2 interacting genes: IMMT RNF7
Entrez ID		9616	23659
HPRD ID		04840	07128
Ensembl ID		ENSG00000114125	ENSG00000103066
Uniprot IDs		Q9UBF6	Q8NCC3
PDB IDs		2ECL	4X90 4X91 4X92 4X93 4X94 4X95 4X97 6MTW
Enriched GO Terms of Interacting Partners?
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