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NCOR2 and SUMO1
Data Source:
BioGRID
(enzymatic study)
NCOR2
SUMO1
Description
nuclear receptor corepressor 2
small ubiquitin like modifier 1
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Membrane
Nuclear Matrix
Nuclear Body
Transcription Repressor Complex
Nucleus
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Nucleolus
Cytosol
Plasma Membrane
Voltage-gated Potassium Channel Complex
Nuclear Body
PML Body
Nuclear Speck
Nuclear Membrane
Nuclear Stress Granule
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Corepressor Activity
Notch Binding
Protein Binding
Nuclear Hormone Receptor Binding
Glucocorticoid Receptor Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Retinoid X Receptor Binding
Protein N-terminus Binding
RNA Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Enzyme Binding
Protein Tag
Ubiquitin Protein Ligase Binding
Small Protein Activating Enzyme Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin-specific Protease Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Lactation
Response To Organonitrogen Compound
Regulation Of Cellular Ketone Metabolic Process
Regulation Of Lipid Metabolic Process
Response To Estradiol
Estrous Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Negative Regulation Of Transcription By RNA Polymerase II
DNA Repair
Double-strand Break Repair Via Nonhomologous End Joining
Viral Process
Protein Sumoylation
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Cellular Response To Heat
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Action Potential
Negative Regulation Of Transcription, DNA-templated
Protein Stabilization
Roof Of Mouth Development
Regulation Of Interferon-gamma-mediated Signaling Pathway
Cellular Response To Cadmium Ion
Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMO E3 ligases SUMOylate target proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
Regulation of IFNG signaling
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
Drugs
Diseases
GWAS
Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) (
23648065
)
Appendicular lean mass (
33097823
)
Clubfoot (
24667120
)
Cocaine dependence (
23958962
)
Cognitive performance (
19734545
)
Diastolic blood pressure (
30224653
)
HDL cholesterol levels (
32203549
)
Height (
31562340
)
Lung function (FEV1) (
30061609
)
Mean spheric corpuscular volume (
32888494
)
Mosquito bite size (
28199695
)
Multiple sclerosis (
31604244
)
Platelet distribution width (
32888494
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
89 interacting genes:
ADRB2
AHR
AKT1
AP2M1
AR
ARNT
ATXN1
ATXN1L
BCL6
C1D
CBFA2T2
CDK2
CEBPB
CEP63
CHUK
CIR1
CNOT2
DDX20
E2F1
ESR1
ESR2
FOS
FOXP1
H4C1
HDAC1
HDAC10
HDAC3
HDAC4
HDAC5
HDAC7
HNF4A
INPP5K
IRF5
JUN
KLF5
MYBL2
MYOD1
NCOA3
NCOA6
NCOR1
NFE2L2
NFKB1
NFKBIA
NFKBIB
NFKBIE
NR1D1
NR1H2
NR1H4
NR1I2
NR2F1
NR2F2
NR3C1
NR4A1
PIN1
PML
POU2F1
PPARA
PPARD
PPARG
RANBP9
RARA
RARB
RARG
RBPJ
RELA
RUNX1
RUNX1T1
RXRA
RXRG
SAP30
SIN3A
SKIL
SNW1
SP1
SPEN
SRF
STAT5A
STAT5B
SUMO1
TBL1X
THRA
THRB
TNIK
TNIP2
UBE2I
VDR
YWHAE
ZBTB16
ZBTB7A
151 interacting genes:
AR
ATF2
ATXN1
ATXN3
ATXN7
AXIN1
BIRC3
BLM
BRCA1
BTBD3
C11orf65
C18orf25
CANX
CARD9
CASP2
CASP8
CCR2
CDK6
CHAF1A
CHD3
CREBBP
DAXX
DEUP1
DNM1
DNMT3B
DTX2
EDARADD
EGLN3
EIF2AK2
ERCC6
ETV6
FAF1
FAM118B
FAS
FASLG
FBF1
FOS
FOXM1
GMCL1
HDAC4
HDAC9
HGS
HIF1A
HIPK2
HIPK3
HNRNPC
HNRNPK
HSF1
HTT
IKZF3
IRAK1
JUN
MAPK1IP1L
MDM2
MEF2A
MITF
MRE11
MRTFA
MSX1
MTOR
MUL1
MYB
NCOA1
NCOA2
NCOA3
NCOR2
NFE2L2
NFKBIA
NIN
NR3C1
NR3C2
PARK7
PAX6
PCNA
PDGFC
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PKM
PLAGL1
PML
PPM1J
PRKN
PROP1
PSIP1
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RHOXF2
RNF111
RNF167
RNF4
RPS3
SAE1
SALL1
SATB1
SENP1
SENP2
SENP6
SETX
SLC2A1
SOX10
SOX2
SOX6
SP100
SP3
SPOP
SREBF1
SREBF2
SUMO1P1
TDG
TDP2
TFCP2
TMIE
TNFRSF1A
TOE1
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP73
TRAF2
TRAF4
TRAF5
TRIM24
TRPS1
TSC22D3
UBA2
UBE2I
USP25
USPL1
WRN
XPO1
ZBTB16
ZBTB2
ZBTB26
ZBTB6
ZCCHC12
ZCCHC7
ZFP42
ZHX1
ZMYM2
ZMYM3
ZMYM5
ZNF451
Entrez ID
9612
7341
HPRD ID
02910
03554
Ensembl ID
ENSG00000196498
ENSG00000116030
Uniprot IDs
C9J0Q5
C9JE98
Q9Y618
A0A024R3Z2
P63165
PDB IDs
1KKQ
1R2B
1XC5
2GPV
2L5G
2LTP
2ODD
2RT5
3R29
3R2A
4A69
4OAR
5X8Q
5X8X
5ZOO
5ZOP
6A22
6IVX
6PDZ
1A5R
1TGZ
1WYW
1Y8R
1Z5S
2ASQ
2BF8
2G4D
2IO2
2IY0
2IY1
2KQS
2LAS
2MW5
2N1A
2N1V
2PE6
2UYZ
2VRR
3KYC
3KYD
3RZW
3UIP
4WJN
4WJO
4WJP
4WJQ
5AEK
5B7A
5ELJ
5GHD
6EOP
6EOT
6J4I
6JXU
6JXV
6K5T
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
6UYX
6UYY
6UYZ
6V7P
6V7Q
6V7R
6V7S
6WW3
Enriched GO Terms of Interacting Partners
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