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CD44 and COL1A1
Data Source:
HPRD
(in vitro)
CD44
COL1A1
Description
CD44 molecule (Indian blood group)
collagen type I alpha 1 chain
Image
GO Annotations
Cellular Component
Golgi Apparatus
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Microvillus
Focal Adhesion
Cell Surface
Basolateral Plasma Membrane
Apical Plasma Membrane
Secretory Granule Membrane
Lamellipodium Membrane
Macrophage Migration Inhibitory Factor Receptor Complex
Cell Projection
Extracellular Exosome
Extracellular Region
Collagen Type I Trimer
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Apparatus
Secretory Granule
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
Transmembrane Signaling Receptor Activity
Cytokine Receptor Activity
Protein Binding
Collagen Binding
Hyaluronic Acid Binding
Protease Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Identical Protein Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
Inflammatory Response
Cell Adhesion
Cell-matrix Adhesion
Cell Migration
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Hyaluronan Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Heterotypic Cell-cell Adhesion
T Cell Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Wound Healing, Spreading Of Cells
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Cartilage Development
Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Monocyte Aggregation
Cell-cell Adhesion
Positive Regulation Of Monocyte Aggregation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Lamellipodium Morphogenesis
Skeletal System Development
Ossification
Blood Vessel Development
Osteoblast Differentiation
Intramembranous Ossification
Endochondral Ossification
Blood Coagulation
Visual Perception
Sensory Perception Of Sound
Response To Mechanical Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Cell-substrate Adhesion
Protein Transport
Platelet Activation
Extracellular Matrix Organization
Collagen Fibril Organization
Positive Regulation Of Cell Migration
Response To Corticosteroid
Response To Estradiol
Collagen Biosynthetic Process
Protein Localization To Nucleus
Tooth Mineralization
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Response To Drug
Response To Hydrogen Peroxide
Response To Peptide Hormone
Skin Development
Skin Morphogenesis
Cellular Response To Fibroblast Growth Factor Stimulus
Tooth Eruption
Positive Regulation Of Transcription, DNA-templated
Embryonic Skeletal System Development
Regulation Of Immune Response
Leukocyte Migration
Response To CAMP
Response To Hyperoxia
Face Morphogenesis
Bone Trabecula Formation
Cartilage Development Involved In Endochondral Bone Morphogenesis
Cellular Response To Amino Acid Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Retinoic Acid
Cellular Response To Vitamin E
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Cellular Response To Fluoride
Pathways
Degradation of the extracellular matrix
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Hyaluronan uptake and degradation
Neutrophil degranulation
Interferon gamma signaling
GPVI-mediated activation cascade
Collagen degradation
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
RUNX2 regulates osteoblast differentiation
Collagen chain trimerization
Drugs
Bivatuzumab
Hyaluronic acid
Collagenase clostridium histolyticum
Halofuginone
Clove oil
Vonicog Alfa
Von Willebrand Factor Human
Diseases
Gastric cancer
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
Infantile cortical hyperostosis; Caffey disease
Osteogenesis imperfecta
GWAS
Bone mineral density (hip) (
30172743
)
Glycemic traits (pleiotropy) (
31021400
)
Intake of sweets (
31005972
)
Response to Vitamin E supplementation (
22437554
)
Systemic lupus erythematosus (
27399966
23273568
26502338
28714469
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Total body bone mineral density (
29304378
)
Uterine fibroids (
31649266
)
Vitiligo (
27723757
22561518
)
Blood cell traits (multivariate analysis) (
31080455
)
Breast cancer (
17903305
)
Heel bone mineral density (
30598549
)
Response to taxane treatment (docetaxel) (
23006423
)
Interacting Genes
61 interacting genes:
ABCB5
AKT1
ANK1
ARHGEF1
ARHGEF12
ARNT
CCND2
CD4
CD74
CDK4
CDK6
CDKN2A
CDKN2B
COL14A1
COL1A1
COL1A2
CSK
DMP1
EGFR
EPB41
EPHA2
ERBB2
ERBB4
EZR
FGF2
FGFR4
FN1
FYN
GARS1
GLIS2
GRM1
HBEGF
HMMR
IGFBP3
KDELR2
LATS2
LCK
MADCAM1
MAP2K3
MAP2K5
MDM4
MET
MMP1
MMP7
MMP9
MSN
NF2
PDGFRA
PKN1
RAF1
SELE
SPP1
SRC
SRGN
STK11
TGFBR1
TGFBR2
TIAM1
VAV2
VCAN
VHL
40 interacting genes:
ATP13A2
BARD1
BGN
BMP1
BRCA1
CAPN1
CD36
CD44
CD93
CDC42
COL7A1
DCN
DDR2
FGF7
FN1
HTRA1
IGFBP3
ITGA2
ITGA5
KEAP1
MAG
MATN2
MCPH1
MMP2
MMP9
NID1
NID2
P4HB
PAK1
PDGFA
PDGFB
PKD1
PRELP
SPARC
TGFBI
THBS1
TMPRSS6
TXN
UBC
VWF
Entrez ID
960
1277
HPRD ID
00115
00362
Ensembl ID
ENSG00000026508
ENSG00000108821
Uniprot IDs
P16070
P02452
PDB IDs
1POZ
1UUH
2I83
4PZ3
4PZ4
6TXS
1Q7D
2LLP
3EJH
3GXE
5CTD
5CTI
5CVA
5CVB
5K31
5OU8
5OU9
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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