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BCAR1 and PLPP3
Data Source:
HPRD
(in vitro)
BCAR1
PLPP3
Description
BCAR1 scaffold protein, Cas family member
phospholipid phosphatase 3
Image
No pdb structure
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Lamellipodium
Axon
Golgi Membrane
Endoplasmic Reticulum Membrane
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Integral Component Of Plasma Membrane
Adherens Junction
Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Membrane Raft
Endoplasmic Reticulum Exit Site
Molecular Function
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Integrin Binding
Protein Binding
Phosphatidate Phosphatase Activity
Sphingosine-1-phosphate Phosphatase Activity
Lipid Phosphatase Activity
Ceramide-1-phosphate Phosphatase Activity
Biological Process
Regulation Of Cell Growth
Actin Filament Organization
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Insulin Receptor Signaling Pathway
Positive Regulation Of Endothelial Cell Migration
Cell Migration
Positive Regulation Of Cell Migration
Cellular Response To Hepatocyte Growth Factor Stimulus
Regulation Of Apoptotic Process
Platelet-derived Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Cell Division
Cell Chemotaxis
Endothelin Receptor Signaling Pathway
Actin Filament Reorganization
Negative Regulation Of Protein Phosphorylation
Phospholipid Metabolic Process
Sphingosine Metabolic Process
Ceramide Metabolic Process
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Signal Transduction
Integrin-mediated Signaling Pathway
Regulation Of Wnt Signaling Pathway
Sphingolipid Biosynthetic Process
Cell-cell Adhesion Mediated By Integrin
Homotypic Cell-cell Adhesion
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Endothelial Cell Migration
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cell-cell Adhesion
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Wound Healing
Phospholipid Dephosphorylation
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Pathways
Downstream signal transduction
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS
Advanced age-related macular degeneration (
26691988
)
Alcoholic chronic pancreatitis (
28754779
)
Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) (
30940143
)
Coronary artery disease (
33020668
)
Crohn's disease (time to surgery) (
23665963
)
Intracranial aneurysm (
33199917
)
Offspring birth weight (
31043758
)
Pancreatic cancer (
29422604
25086665
)
Type 1 diabetes (
25751624
)
Type 2 diabetes (
22885922
29358691
30297969
)
Coronary artery disease (
30104761
33020668
)
Heel bone mineral density (
30598549
)
Low density lipoprotein cholesterol levels (
29403010
)
Interacting Genes
65 interacting genes:
ABL1
AJUBA
ANKS1A
ARHGAP32
BMX
CASP3
CD2AP
COPB1
CRK
CRKL
CSPG4
DOCK1
DOK7
E2F2
EFS
ESR1
FAM102A
FAM90A1
FES
FXYD6
FYB1
FYN
GLIS2
GRB2
GSN
HCK
HSPA5
INPPL1
LCK
LYN
MMP14
NCK1
NCK2
NEDD9
NPHP1
PIK3R1
PKD1
PLPP3
PPP1R15A
PRAM1
PTEN
PTK2
PTK2B
PTPN1
PTPN12
PTPRA
PTPRF
PTPRH
PXN
RAN
RAPGEF1
SH2D3A
SH2D3C
SH3KBP1
SRC
SRCIN1
TNS3
TRIP6
TUBA4A
UHRF2
USP2
VCL
VPS11
YES1
YWHAZ
4 interacting genes:
APP
BCAR1
CTNND1
SHC1
Entrez ID
9564
8613
HPRD ID
04248
06179
Ensembl ID
ENSG00000050820
ENSG00000162407
Uniprot IDs
B3KWE2
P56945
O14495
PDB IDs
1WYX
3T6G
5O2M
5O2P
5O2Q
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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