APBA3 and BCR

Data Source:
HPRD (in vitro, in vivo)

		APBA3	BCR
Description		amyloid beta precursor protein binding family A member 3	BCR activator of RhoGEF and GTPase
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Dendritic Spine Perinuclear Region Of Cytoplasm	Cytosol Membrane Axon Protein-containing Complex Dendritic Spine Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Amyloid-beta Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	In Utero Embryonic Development Chemical Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Keratinocyte Differentiation Regulation Of Rho Protein Signal Transduction Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		Neurexins and neuroligins	Signaling by cytosolic FGFR1 fusion mutants Rho GTPase cycle Signaling by FGFR1 in disease
Drugs			Imatinib Dasatinib Bosutinib Ponatinib
Diseases			Chronic myeloid leukemia (CML) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS			Asthma ( 27611488) Coenzyme Q10 levels ( 27149984) Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470) Kidney stones ( 31729369) Left-handedness ( 32989287)
Interacting Genes		8 interacting genes: APP ARF3 ARF4 AZI2 BCR EGFR TANK TBKBP1	45 interacting genes: ABL1 ABL2 AFDN APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 PLCG1 PTPN1 PTPN11 PTPN6 RAC1 RAD51 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UBC UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		9546	613
HPRD ID		05038	01044
Ensembl ID		ENSG00000011132	ENSG00000186716
Uniprot IDs		O96018	P11274
PDB IDs		2YT7 2YT8 5UWS	1K1F 2AIN 5N6R 5N7E 5OC7
Enriched GO Terms of Interacting Partners?
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