POLR1C and CBY2

Data Source:
BioGRID (two hybrid, two hybrid)

		POLR1C	CBY2
Description		RNA polymerase I and III subunit C	chibby family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm RNA Polymerase III Complex RNA Polymerase I Complex Cytosol	Cytoplasmic Vesicle
	Molecular Function	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein Dimerization Activity	Protein Binding
	Biological Process	Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Gene Expression, Epigenetic
Pathways		Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases		Treacher Collins syndrome
GWAS		GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		119 interacting genes: ADAMTSL4 ARHGEF5 ATRIP AVPI1 BHLHB9 BIN3 BIRC7 BLZF1 C1orf105 C21orf58 C4orf45 CBX8 CBY2 CCDC33 CCNK CCT3 CGGBP1 CLU CORO1A CORO1B CRACR2A EFHC2 EP400 FH FMR1 FOXR2 GAS8 GMPPB GOLGA6A GOLGA6L9 GRPEL1 GSTO2 HDX HNRNPH1 HOXB9 HOXD12 IHO1 IKZF3 INCA1 KCTD1 KCTD13 KLF15 KRT19 KRT75 KRT76 KRTAP12-2 KRTAP3-1 LNX2 LRIF1 LZTS1 LZTS2 MBIP MEI4 MEOX2 MKRN3 MORN3 MRPS23 MYD88 MYO5B NDUFB10 NEDD4 NFKBIB NIF3L1 NME1 NME4 PIH1D2 POLDIP3 POLR1D POLR1E POLR1G POLR2G POLR2J POLR2J3 PPP2R3C PSMA1 RBM48 RIMBP3 RIMBP3C RSPH14 RUSC1 SAXO1 SMN1 SMN2 SORBS3 SPATC1L SPRY1 STMN3 TASOR2 TAX1BP1 TCF4 TEX43 TFIP11 TLE5 TMEM121 TNFAIP1 TNNI1 TRAIP TRIM14 TRIM27 TRIOBP TSC22D4 UNKL USP54 VIM WASHC1 WRN XPA YPEL3 ZBED1 ZBTB42 ZC2HC1C ZFP57 ZIM2 ZNF547 ZNF554 ZNF655 ZNF688 ZNF835 ZRANB1	119 interacting genes: ACTN1 AIMP2 ARHGEF40 ARMC7 BEX3 C19orf44 C1orf109 CCDC146 CCDC185 CCDC187 CCDC198 CCDC57 CCHCR1 CCNG1 CDC23 CDC37 CDK18 CDK2 CEP44 CEP55 CEP57L1 CEP95 CHCHD3 CHIC2 CIBAR1 CKS1B CNNM3 CYTH4 DGCR6 DTNB DUSP14 DZIP1L EFCAB3 EIF4E2 ELOA ENKD1 FAM161A FANCG FARS2 FBXO17 FRS3 GADD45A GADD45GIP1 GOLGA2 GOLGA6A GOLGA6L2 GRAP2 HAUS1 HSF2BP ING5 ISCU KIAA0408 KIFC3 KLC3 LATS1 LENG1 LMO1 LMO2 LMO3 LNX1 MCRS1 MED28 METTL17 MLH1 MMAB MOS NDUFA5 NEK6 NINL NME7 NTAQ1 OIP5 PID1 PIN1 PLEKHN1 POLR1C PPFIA3 PPP1R13B PPP1R18 PRPF18 PRPF31 RCOR3 RNF6 RPL9 RTP5 RUNX1T1 SCNM1 SDCBP SH3RF2 SNAPC5 SSX3 SYCE1 SYT17 TCEA2 TCEANC TCHP TEX11 TRIM42 TRIML2 TSC2 TSGA10 TSGA10IP TUBGCP4 TXK TXLNA TXLNB USHBP1 ZC2HC1C ZFYVE26 ZMAT2 ZNF250 ZNF417 ZNF564 ZNF572 ZNF581 ZNF655 ZNF688 ZNF764 ZNF785
Entrez ID		9533	220082
HPRD ID		09661	14856
Ensembl ID		ENSG00000171453	ENSG00000174015
Uniprot IDs		O15160	A0A140VJV5 Q8NA61
PDB IDs
Enriched GO Terms of Interacting Partners?
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