CD38 and PECAM1

Data Source:
HPRD (in vitro)

		CD38	PECAM1
Description		CD38 molecule	platelet and endothelial cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Basolateral Plasma Membrane Secretory Granule Membrane Extracellular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Secretory Granule Membrane Platelet Alpha Granule Membrane Protein-containing Complex Membrane Raft Extracellular Exosome
	Molecular Function	NAD+ Nucleosidase Activity Transferase Activity Phosphorus-oxygen Lyase Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Response To Hypoxia Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Female Pregnancy Negative Regulation Of Neuron Projection Development Artery Smooth Muscle Contraction NAD Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Insulin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Hydroperoxide Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction B Cell Receptor Signaling Pathway Long-term Synaptic Depression Response To Interleukin-1 Apoptotic Signaling Pathway	Positive Regulation Of Protein Phosphorylation Platelet Degranulation Phagocytosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Cell Recognition Extracellular Matrix Organization Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Monocyte Extravasation Neutrophil Degranulation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Diapedesis Establishment Of Endothelial Barrier Bicellular Tight Junction Assembly Glomerular Endothelium Development Neutrophil Extravasation Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Protein Localization To Cell-cell Junction
Pathways		Nicotinate metabolism	Platelet degranulation Cell surface interactions at the vascular wall PECAM1 interactions Integrin cell surface interactions Platelet sensitization by LDL Neutrophil degranulation
Drugs		Daratumumab Isatuximab Mezagitamab
Diseases
GWAS		Blood protein levels ( 28240269) Neurological blood protein biomarker levels ( 31320639) Parkinson's disease ( 27182965 28892059)	Coronary artery disease ( 32469254 29212778 33020668) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878)
Interacting Genes		6 interacting genes: CBL CD4 CD9 FCGR3A LCK PECAM1	22 interacting genes: CD38 CSK CTNNB1 DSP EFNB2 FYN HCK INPP5D ITGA5 ITGB3 JUP LCK LYN PIK3R1 PLCG1 PRKCE PRPF40A PTPN11 PTPN6 SRC XRCC6 YES1
Entrez ID		952	5175
HPRD ID		00116	01425
Ensembl ID		ENSG00000004468	ENSG00000261371
Uniprot IDs		B4E006 P28907	P16284
PDB IDs		1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ 3ROK 3ROM 3ROP 3ROQ 3U4H 3U4I 4CMH 4F45 4F46 4OGW 4TMF 4XJS 4XJT 5F1K 5F1O 5F21 6EDR 6VUA	2KY5 5C14 5GNI
Enriched GO Terms of Interacting Partners?
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