CD33 and CYB5B

Data Source:
BioGRID (two hybrid)

		CD33	CYB5B
Description		CD33 molecule	cytochrome b5 type B
Image
GO Annotations	Cellular Component	Nucleoplasm Peroxisome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Specific Granule Membrane Tertiary Granule Membrane	Mitochondrial Outer Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Nitric-oxide Synthase Complex
	Molecular Function	Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity	Protein Binding Enzyme Activator Activity Electron Transfer Activity Heme Binding Metal Ion Binding Nitrite Reductase (NO-forming) Activity
	Biological Process	Immune Response-inhibiting Signal Transduction Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Neutrophil Degranulation Positive Regulation Of Protein Secretion Regulation Of Immune Response Negative Regulation Of Calcium Ion Transport Cell-cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Protein Tyrosine Phosphatase Activity	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Electron Transport Chain Regulation Of Catalytic Activity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	Phase I - Functionalization of compounds
Drugs		Gemtuzumab ozogamicin AVE9633	Phenethyl Isothiocyanate
Diseases
GWAS		Alzheimer's disease ( 18976728 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Basophil count ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Eosinophil counts ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 susceptibility ( 25786224) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triacylglyceride levels ( 31551469) White blood cell count ( 32888494 27863252)	Blood osmolality (transformed sodium) ( 28360221) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 30993211 29403010)
Interacting Genes		21 interacting genes: BMP10 C3orf52 CXCL9 CYB5B EMD GIMAP5 HERC3 KRT31 KRT35 KRT40 PTPN11 PTPN6 RPRM SCD SRC THSD7A TMBIM1 TMEM100 TMEM243 TNMD UBIAD1	48 interacting genes: AHNAK2 APP AQP6 BIK BNIP3L BTNL9 CD33 CD79A CGRRF1 CLDN7 CLN8 CPLX4 CREB3 EBP FAM209A FAM210B FNDC9 FRMD3 GJB5 GPR152 IGSF9 KCNK5 KIR2DL3 LMNA MARCHF8 MFF MFSD14B MFSD4B MFSD5 MUC1 NDUFAF2 PDZK1IP1 PHACTR3 PLPP4 REEP4 RETREG3 SDHAF4 SLC10A6 SLC16A2 SLC39A9 STOM STX1A SYT1 TMEM139 TMEM237 TMEM35A TMEM41A TMEM86B
Entrez ID		945	80777
HPRD ID		01165	13106
Ensembl ID		ENSG00000105383	ENSG00000103018
Uniprot IDs		P20138 Q546G0	O43169
PDB IDs		5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8	3NER
Enriched GO Terms of Interacting Partners?
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