MAP4K4 and GBP3

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		MAP4K4	GBP3
Description		mitogen-activated protein kinase kinase kinase kinase 4	guanylate binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion	Golgi Membrane Cytoplasm Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Creatine Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	GTPase Activity Protein Binding GTP Binding Protein Homodimerization Activity
	Biological Process	MAPK Cascade Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Microvillus Assembly Positive Regulation Of Cell Migration Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of ARF Protein Signal Transduction Activation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Disassembly	Defense Response To Virus Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Oxidative Stress Induced Senescence	Interferon gamma signaling
Drugs		Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644) Asthma ( 31619474) Asthma (time to onset) ( 27130862) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) White blood cell count ( 32888494)	Carotid intima media thickness ( 26343869)
Interacting Genes		18 interacting genes: BRCA1 CASP8 DOK1 GBP3 H2BC21 ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2	1 interacting genes: MAP4K4
Entrez ID		9448	2635
HPRD ID		05235	02683
Ensembl ID		ENSG00000071054	ENSG00000117226
Uniprot IDs		B7Z3V5 O95819 V9HWH3	Q9H0R5
PDB IDs		4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q
Enriched GO Terms of Interacting Partners?
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