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CD28 and WBP2NL
Data Source:
BioGRID
(affinity chromatography technology)
CD28
WBP2NL
Description
CD28 molecule
WBP2 N-terminal like
Image
No pdb structure
GO Annotations
Cellular Component
Immunological Synapse
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Protein Complex Involved In Cell Adhesion
Nucleus
Perinuclear Theca
Sperm Flagellum
Sperm Head
Molecular Function
Protease Binding
Protein Binding
Coreceptor Activity
Protein Kinase Binding
Identical Protein Binding
Transcription Coactivator Activity
Protein Binding
Chromatin DNA Binding
WW Domain Binding
Biological Process
Cytokine Production
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Humoral Immune Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
T Cell Costimulation
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of T Cell Proliferation
T Cell Activation
Negative Regulation Of Apoptotic Process
Negative Thymic T Cell Selection
Regulatory T Cell Differentiation
Positive Regulation Of Viral Genome Replication
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
Regulation Of Defense Response To Virus By Virus
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Apoptotic Signaling Pathway
Egg Activation
Female Pronucleus Assembly
Male Pronucleus Assembly
Positive Regulation Of Transcription, DNA-templated
Meiotic Cell Cycle
Regulation Of Cytosolic Calcium Ion Concentration
Pathways
PIP3 activates AKT signaling
Nef mediated downregulation of CD28 cell surface expression
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS
Alopecia areata (
25608926
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
20190752
25920553
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Graves' disease (
21841780
)
Heschl's gyrus morphology (
25130324
)
Inflammatory bowel disease (
26192919
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Multiple sclerosis (
31604244
24076602
)
Primary biliary cholangitis (
28425483
)
Primary sclerosing cholangitis (
23603763
27992413
)
Rheumatoid arthritis (
30423114
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Subcutaneous adipose tissue (
29178545
)
Systemic lupus erythematosus (
28714469
)
Ulcerative colitis (
26192919
)
Autism spectrum disorder or schizophrenia (
28540026
)
Breast size (
22747683
)
Estimated glomerular filtration rate (
31217584
)
Feeling tense (
29500382
)
Intelligence (
28530673
)
Isthmus-cingulate cortex volume (
31530798
)
Platelet distribution width (
27863252
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
17 interacting genes:
CD247
CD4
CD80
CD86
DUSP14
GRAP2
GRB2
IL12A
ITK
LCK
LRRC23
NSF
PIK3CG
PIK3R1
PIK3R2
PLCG1
PTPRC
1 interacting genes:
FMR1
Entrez ID
940
164684
HPRD ID
01727
14512
Ensembl ID
ENSG00000178562
ENSG00000183066
Uniprot IDs
B4E0L1
P10747
Q6ICG8
PDB IDs
1YJD
3WA4
5AUL
5GJH
5GJI
6O8D
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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