TRIP10 and PDE6G

Data Source:
HPRD (in vitro, two hybrid)

		TRIP10	PDE6G
Description		thyroid hormone receptor interactor 10	phosphodiesterase 6G
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GO Annotations	Cellular Component	Phagocytic Cup Nucleoplasm Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Cell Cortex Cell Projection Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Enzyme Inhibitor Activity Protein Binding Spectrin Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Endocytosis Cell Communication Signal Transduction Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Membrane Organization	Activation Of MAPK Activity Wnt Signaling Pathway, Calcium Modulating Pathway Visual Perception Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Pathways		Rho GTPase cycle Clathrin-mediated endocytosis	Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway
Drugs			Sildenafil Vardenafil 3-isobutyl-1-methyl-7H-xanthine
Diseases			Retinitis pigmentosa (RP)
GWAS			Blond vs. brown/black hair color ( 30531825) High myopia ( 31816047) Refractive error ( 32231278)
Interacting Genes		41 interacting genes: ABI1 ABL2 AKAP9 ARHGAP12 ARHGAP17 CDC42 CREBBP CTNNB1 DNM2 DTX3 HOXC11 HTT JRK LYN MEOX1 MEOX2 NKX2-5 PAX6 PDE6G POT1 PRKACA RHOJ RHOQ RIN1 RXRA SF3A2 SH3BP1 SMARCE1 SMURF1 SRC STAT3 TERF1 THAP1 THRB TINF2 UTF1 WAS WASF1 WASL WBP11 ZBTB7B	11 interacting genes: BHLHE40 DNM2 FNBP1 GNAO1 GRB2 GRK2 L3MBTL3 MAPK3 PRKAB2 SRC TRIP10
Entrez ID		9322	5148
HPRD ID		05142	08914
Ensembl ID		ENSG00000125733	ENSG00000185527
Uniprot IDs		Q15642 W4VSQ9	P18545
PDB IDs		2CT4 2EFK 2KE4	3JWR
Enriched GO Terms of Interacting Partners?
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