OLFM2 and GNB5

Data Source:
HPRD (two hybrid)

		OLFM2	GNB5
Description		olfactomedin 2	G protein subunit beta 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm AMPA Glutamate Receptor Complex Synapse	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Presynapse GTPase Activator Complex
	Molecular Function	Protein Binding	GTPase Activity GTPase Activator Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding
	Biological Process	Protein Secretion Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation	Protein Folding Signal Transduction G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Positive Regulation Of GTPase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways			Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Menarche (age at onset) ( 27182965 21102462 25231870) Sleep duration ( 30531941)	Lewy body disease ( 25188341)
Interacting Genes		14 interacting genes: BLOC1S6 EIF1 FANCF GNB5 KRTAP1-3 KRTAP10-3 NBAS NBPF19 NOTCH2NLA PKM ROBO2 RPS6 SRSF5 ST13	27 interacting genes: ANXA7 APP BNIP3L CDKN1A CSNK2B DRD2 E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1
Entrez ID		93145	10681
HPRD ID		10127	09191
Ensembl ID		ENSG00000105088	ENSG00000069966
Uniprot IDs		K7EIS8 O95897	A0A024R5R9 A0A024R5V3 O14775
PDB IDs
Enriched GO Terms of Interacting Partners?
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