MAPKAPK2 and ZFP36L1

Data Source:
BioGRID (enzymatic study)

		MAPKAPK2	ZFP36L1
Description		MAPK activated protein kinase 2	ZFP36 ring finger protein like 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Extracellular Exosome	P-body Nucleus Cytoplasm Cytosol Ribonucleoprotein Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding 14-3-3 Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Protein Phosphorylation Leukotriene Metabolic Process Inflammatory Response Cellular Response To DNA Damage Stimulus Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Response To Cytokine Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Regulation Of MRNA Stability Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Inner Ear Development 3'-UTR-mediated MRNA Stabilization Regulation Of Cellular Response To Heat	MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Vasculogenesis Proepicardium Development MRNA Processing Apoptotic Process Heart Development Cell Population Proliferation Response To Wounding Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Phosphatidylinositol 3-kinase Signaling Neural Tube Development Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Regulation Of MRNA 3'-end Processing Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Multicellular Organism Growth P38MAPK Cascade Regulation Of MRNA Stability Protein Kinase B Signaling Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Monocyte Differentiation Regulation Of Myoblast Differentiation Mesendoderm Development MRNA Transport Chorio-allantoic Fusion 3'-UTR-mediated MRNA Destabilization ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Stem Cell Proliferation Cellular Response To Raffinose Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intracellular MRNA Localization
Pathways		p38MAPK events CREB phosphorylation Synthesis of Leukotrienes (LT) and Eoxins (EX) Oxidative Stress Induced Senescence Regulation of HSF1-mediated heat shock response VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Drugs		Staurosporine 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Blood protein levels ( 28240269) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Mean corpuscular hemoglobin ( 32888494)	Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 31959851) Blond vs. brown/black hair color ( 30531825) Celiac disease ( 22057235 20190752 25920553) Crohn's disease ( 21102463) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure ( 30224653) Fibrinogen levels ( 28107422 26561523) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Inflammatory bowel disease ( 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 31511532) Multiple sclerosis ( 24076602 21833088) Nonsyndromic cleft lip ( 31609978) Prostate cancer ( 23535732) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		42 interacting genes: AGO2 AKT1 ALOX5 ARPC5 ATF1 BAG2 BCL2L1 BECN1 CDC25B CEP131 CREB1 DDX5 DES EEF2K ETV1 HNRNPA0 HSF1 HSPB1 LIMK1 LSP1 MAP2K6 MAPK14 MAPK3 MDM2 PABPC1 PARN PHC2 PIAS2 RCSD1 SHC1 SRF STAT3 TCF3 TH TRIM28 TRIM29 TSC2 UBE2J1 WASF1 YWHAZ ZFP36 ZFP36L1	9 interacting genes: ACD AKT1 MAPK14 MAPKAPK2 PAFAH1B2 POT1 TERF1 TINF2 YWHAB
Entrez ID		9261	677
HPRD ID		11882	03041
Ensembl ID		ENSG00000162889	ENSG00000185650
Uniprot IDs		P49137	A0A024R658 B3KNA8 Q07352
PDB IDs		1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30 3WI6 4TYH 6TCA	1W0V 1W0W
Enriched GO Terms of Interacting Partners?
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