RAB11B and SREBF2

Data Source:
HPRD (two hybrid)

		RAB11B	SREBF2
Description		RAB11B, member RAS oncogene family	sterol regulatory element binding transcription factor 2
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GO Annotations	Cellular Component	Endosome Cytosol Synaptic Vesicle Phagocytic Vesicle Membrane Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding Cadherin Binding	C-8 Sterol Isomerase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Receptor Recycling Exocytosis Melanosome Transport Transferrin Transport Insulin Secretion Involved In Cellular Response To Glucose Stimulus Post-translational Protein Modification Regulation Of Anion Transport Constitutive Secretory Pathway Regulated Exocytosis Cellular Response To Acidic PH Establishment Of Protein Localization To Membrane Amyloid-beta Clearance By Transcytosis Retrograde Transport, Endosome To Plasma Membrane Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		TBC/RABGAPs RAB geranylgeranylation	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 31043758 27680694) General cognitive ability ( 29844566) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		11 interacting genes: APP IKBKG MEOX2 MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SH3BP5L SREBF2	50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX
Entrez ID		9230	6721
HPRD ID		05009	02726
Ensembl ID		ENSG00000185236	ENSG00000198911
Uniprot IDs		Q15907	A0A024R1Q0 Q12772
PDB IDs		2F9L 2F9M 4OJK	1UKL
Enriched GO Terms of Interacting Partners?
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