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ACVR2A and BMP4
Data Source:
BioGRID
(pull down)
ACVR2A
BMP4
Description
activin A receptor type 2A
bone morphogenetic protein 4
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Inhibin-betaglycan-ActRII Complex
Receptor Complex
Activin Receptor Complex
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Molecular Function
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Coreceptor Activity
Activin-activated Receptor Activity
Growth Factor Binding
PDZ Domain Binding
Inhibin Binding
Protein Self-association
Metal Ion Binding
Activin Binding
BMP Receptor Activity
Cytokine Activity
Protein Binding
Growth Factor Activity
Heparin Binding
Co-receptor Binding
Chemoattractant Activity
BMP Receptor Binding
Biological Process
Gastrulation With Mouth Forming Second
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Spermatogenesis
Determination Of Left/right Symmetry
Mesoderm Development
Anterior/posterior Pattern Specification
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Positive Regulation Of Activin Receptor Signaling Pathway
Sperm Ejaculation
Penile Erection
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Skeletal System Development
Regulation Of Nitric-oxide Synthase Activity
Sertoli Cell Proliferation
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPKK Activity
Osteoblast Differentiation
Ureteric Bud Development
Branching Involved In Ureteric Bud Morphogenesis
Kidney Development
Mesonephros Development
Neural Tube Closure
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Endochondral Ossification
Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Chondrocyte Differentiation
Hematopoietic Progenitor Cell Differentiation
Lymphoid Progenitor Cell Differentiation
Renal System Process
BMP Signaling Pathway Involved In Heart Induction
Secondary Heart Field Specification
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Muscular Septum Morphogenesis
Aortic Valve Morphogenesis
Pulmonary Valve Morphogenesis
Endocardial Cushion Development
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cardiac Right Ventricle Morphogenesis
Apoptotic Process Involved In Endocardial Cushion Morphogenesis
Cardiac Septum Development
Type B Pancreatic Cell Development
Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Common-partner SMAD Protein Phosphorylation
Germ Cell Development
Endoderm Development
Mesodermal Cell Fate Determination
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Post-embryonic Development
Anterior/posterior Axis Specification
Specification Of Animal Organ Position
Regulation Of Cell Fate Commitment
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Cell Death
Telencephalon Development
Dorsal/ventral Neural Tube Patterning
Telencephalon Regionalization
Pituitary Gland Development
Erythrocyte Differentiation
Monocyte Differentiation
Macrophage Differentiation
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Binding
Negative Regulation Of Chondrocyte Differentiation
Positive Regulation Of Collagen Biosynthetic Process
Negative Regulation Of T Cell Differentiation In Thymus
Negative Regulation Of Immature T Cell Proliferation In Thymus
Protein Localization To Nucleus
Embryonic Hindlimb Morphogenesis
Tendon Cell Differentiation
Deltoid Tuberosity Development
Regulation Of Protein Import Into Nucleus
Negative Regulation Of Phosphorylation
Odontogenesis Of Dentin-containing Tooth
Odontogenesis
Regulation Of Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Steroid Hormone Mediated Signaling Pathway
Negative Regulation Of MAP Kinase Activity
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Endothelial Cell Differentiation
Positive Regulation Of Epidermal Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Ossification
Negative Regulation Of Cell Cycle
Negative Regulation Of Mitotic Nuclear Division
Negative Regulation Of Striated Muscle Tissue Development
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Lung Alveolus Development
Intermediate Mesodermal Cell Differentiation
Positive Regulation Of Smooth Muscle Cell Proliferation
Neuron Fate Commitment
Embryonic Cranial Skeleton Morphogenesis
Smooth Muscle Tissue Development
Branching Morphogenesis Of An Epithelial Tube
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Positive Chemotaxis
Regulation Of Smooth Muscle Cell Differentiation
Cardiac Muscle Cell Differentiation
Positive Regulation Of Cardiac Muscle Fiber Development
Inner Ear Receptor Cell Differentiation
Cloacal Septation
Lens Induction In Camera-type Eye
Embryonic Skeletal Joint Morphogenesis
Cranial Suture Morphogenesis
Positive Regulation Of SMAD Protein Signal Transduction
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
SMAD Protein Signal Transduction
Lung Morphogenesis
Bronchus Development
Trachea Development
Trachea Formation
Epithelial Tube Branching Involved In Lung Morphogenesis
Branching Involved In Prostate Gland Morphogenesis
Bud Elongation Involved In Lung Branching
Epithelial Cell Proliferation Involved In Lung Morphogenesis
Bud Dilation Involved In Lung Branching
Negative Regulation Of Cell Death
Mammary Gland Formation
Epithelial-mesenchymal Cell Signaling
Negative Regulation Of Prostatic Bud Formation
Regulation Of Branching Involved In Prostate Gland Morphogenesis
Coronary Vasculature Development
Positive Regulation Of Cartilage Development
Positive Regulation Of Branching Involved In Lung Morphogenesis
BMP Signaling Pathway Involved In Ureter Morphogenesis
BMP Signaling Pathway Involved In Renal System Segmentation
Pulmonary Artery Endothelial Tube Morphogenesis
BMP Signaling Pathway Involved In Heart Development
Pharyngeal Arch Artery Morphogenesis
Negative Regulation Of Thymocyte Apoptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To BMP Stimulus
BMP Signaling Pathway Involved In Nephric Duct Formation
Glomerular Visceral Epithelial Cell Development
Negative Regulation Of Branch Elongation Involved In Ureteric Bud Branching By BMP Signaling Pathway
Specification Of Ureteric Bud Anterior/posterior Symmetry By BMP Signaling Pathway
Glomerular Capillary Formation
Negative Regulation Of Glomerular Mesangial Cell Proliferation
Mesenchymal Cell Proliferation Involved In Ureteric Bud Development
Mesenchymal Cell Differentiation Involved In Kidney Development
Ureter Epithelial Cell Differentiation
Ureter Smooth Muscle Cell Differentiation
Mesenchymal Cell Proliferation Involved In Ureter Development
Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development
Metanephric Collecting Duct Development
Positive Regulation Of Kidney Development
Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Negative Regulation Of Glomerulus Development
Positive Regulation Of Cell Proliferation Involved In Outflow Tract Morphogenesis
Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Cardiac Jelly Development
Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Negative Regulation Of Metanephric S-shaped Body Morphogenesis
Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis
Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Signaling by NODAL
Regulation of signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
Molecules associated with elastic fibres
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Drugs
Sotatercept
Calcium
Diseases
Anophthalmia and microphthalmia (A/M)
GWAS
Adult body size (
32376654
)
Adventurousness (
30643258
)
Arterial stiffness index (
31235810
)
Asthma (adult onset) (
31036433
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
27863252
)
Cerebrospinal T-tau levels (
28247064
)
Diastolic blood pressure (
30224653
)
Eosinophil counts (
32888494
)
Estimated glomerular filtration rate (
31015462
)
Feeling hurt (
29500382
)
Feeling miserable (
29500382
)
Feeling nervous (
29500382
)
Feeling tense (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Glomerular filtration rate (creatinine) (
26831199
)
HDL cholesterol levels (
32203549
)
High myopia (
31816047
)
Loneliness (MTAG) (
29970889
)
Neutrophil percentage of granulocytes (
27863252
)
Photic sneeze reflex (
30899065
)
Refractive error (
32231278
)
Response to statin therapy (
20339536
)
Retinal detachment or retinal break (
31816047
)
Urate levels (
31985003
23263486
)
White blood cell count (basophil) (
27863252
)
Blond vs. brown/black hair color (
30531825
)
Brain morphology (MOSTest) (
32665545
)
Chin dimples (
27182965
)
Colorectal cancer (
25990418
19011631
26151821
)
Colorectal cancer or advanced adenoma (
30510241
)
Dental caries (
23259602
)
Estimated glomerular filtration rate (
31152163
)
Glomerular filtration rate (creatinine) (
26831199
)
Heel bone mineral density (
30598549
28869591
)
High myopia (
31816047
)
Immune reponse to smallpox (secreted IFN-alpha) (
22610502
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Lung function (FEV1/FVC) (
30804560
)
Monobrow thickness (
26926045
)
Myopia (
27182965
)
Optic cup area (
25631615
)
Optic disc size (
31809533
)
Parkinson's disease (
19915575
)
Peak expiratory flow (
30804560
)
Primary tooth development (time to first tooth eruption) (
23704328
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Waist-to-hip ratio adjusted for body mass index (
27195708
)
Interacting Genes
23 interacting genes:
ACVRL1
BMP10
BMP2
BMP4
BMP6
BMP7
DAXX
DYNLT4
ENG
ERBIN
GDF2
GDF5
GDF9
IGSF1
INHBA
INHBB
INHBC
MAGI2
NODAL
PRSS50
SYNJ2BP
TDGF1
TGFBR3
18 interacting genes:
ACVR2A
BGN
BMP8B
BMPER
BMPR1A
BMPR1B
BMPR2
CHRDL1
CHRDL2
GREM2
HTRA1
NOG
RGMB
SOSTDC1
STAP2
TDGF1
TWSG1
ZFYVE9
Entrez ID
92
652
HPRD ID
00025
00207
Ensembl ID
ENSG00000121989
ENSG00000125378
Uniprot IDs
P27037
P12644
Q53XC5
PDB IDs
3Q4T
3SOC
4ASX
5NH3
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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