RFT1 and RNF144A

Data Source:
BioGRID (two hybrid)

		RFT1	RNF144A
Description		RFT1 homolog	ring finger protein 144A
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Plasma Membrane Endosome Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Carbohydrate Transport Glycolipid Translocation	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective RFT1 causes RFT1-CDG (CDG-1n)	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Crohn's disease ( 28067908) Feeling worry ( 29500382) Height ( 23563607 31562340) High density lipoprotein cholesterol levels ( 31928498) Hip circumference adjusted for BMI ( 25673412) Immune reponse to smallpox (secreted IL-2) ( 22610502) Schizophrenia ( 23974872) Serum uric acid levels ( 30993211 29403010) Type 2 diabetes ( 30297969)	Allergic rhinitis ( 30013184) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Esophageal adenocarcinoma x smoking interaction ( 29551738) Intracranial aneurysm ( 30823506) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Manic episodes in bipolar disorder ( 26297903) Response to antipsychotic treatment ( 20195266)
Interacting Genes		12 interacting genes: AQP6 BEST2 CNR2 CREB3L1 ERGIC3 MUC1 NEDD4 PSMA3 RNF144A TMX2 TNS2 TSPAN12	27 interacting genes: CYSLTR2 DGAT2L6 E2F1 E2F2 E2F3 E2F4 EGFR MFSD5 PAQR6 PARP1 RFT1 SEC22A SGTA SGTB SLC7A1 TMEM31 UBC UBE2D1 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32 YIF1A
Entrez ID		91869	9781
HPRD ID		15239	11510
Ensembl ID		ENSG00000163933	ENSG00000151692
Uniprot IDs		Q96AA3	P50876
PDB IDs			1WIM
Enriched GO Terms of Interacting Partners?
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