IL1RL1 and TSPAN18

Data Source:
BioGRID (two hybrid)

		IL1RL1	TSPAN18
Description		interleukin 1 receptor like 1	tetraspanin 18
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Integral Component Of Membrane	Integral Component Of Plasma Membrane
	Molecular Function	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Negative Regulation Of T-helper 1 Type Immune Response Immune Response Signal Transduction Negative Regulation Of Interferon-gamma Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Inflammatory Response
Pathways		PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling
Drugs
Diseases
GWAS		Adult asthma ( 30578877) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 23028483 21804549 31361310 31959851 30929738 27182965 32296059 31619474 26620591 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 29273806) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752 18311140) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Eosinophil counts ( 29403010 19198610 32888494) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908 23128233) Lung function (FEV1/FVC) ( 30804560) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)	Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Intraocular pressure ( 29785010) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Schizophrenia ( 22037552) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		18 interacting genes: APP ASGR2 CLEC12B CLEC2D CLEC7A CREB3L1 GPR152 GPR42 HRAS IL33 MCFD2 MYD88 SIGLEC12 SLC38A1 TIRAP TMED1 TSPAN18 YIPF6	9 interacting genes: CD151 CXCL9 GIMAP5 GRM2 IL1RL1 OLFM4 TMCO5A TMEM120A TMEM218
Entrez ID		9173	90139
HPRD ID		03123	17435
Ensembl ID		ENSG00000115602	ENSG00000157570
Uniprot IDs		Q01638	Q96SJ8
PDB IDs		4KC3
Enriched GO Terms of Interacting Partners?
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