HGS and MAP3K1

Data Source:
BioGRID (enzymatic study)

		HGS	MAP3K1
Description		hepatocyte growth factor-regulated tyrosine kinase substrate	mitogen-activated protein kinase kinase kinase 1
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GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Cytosol Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytosol
	Molecular Function	Protein Binding Protein Domain Specific Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding
	Biological Process	Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Population Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Protein Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of MAP Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion	MAPK Cascade Activation Of MAPKK Activity MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Fc-epsilon Receptor Signaling Pathway Cellular Response To Mechanical Stimulus
Pathways		EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle	MyD88:MAL(TIRAP) cascade initiated on plasma membrane FCERI mediated MAPK activation FCERI mediated MAPK activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs		Citric acid	AZD-8330 Binimetinib Fostamatinib
Diseases
GWAS		Eye color traits ( 20463881) Refractive error ( 32231278)	Alanine transaminase levels ( 29403010) Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683 17529967 23535729 31757997 20453838 19330030) Breast cancer (early onset) ( 24493630) Brown vs. black hair color ( 30531825) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Fasting blood insulin ( 25631608) Fasting glucose in pregnancy (gestational week 14-16) ( 30324795) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Initial pursuit acceleration ( 29064472) Lung function (FEV1) ( 30061609) Refractive error ( 32231278) Sexual dimorphism in anthropometric traits ( 23754948) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 28334899) Triglycerides ( 24097068 20686565) Type 2 diabetes ( 23209189) Urate levels (BMI interaction) ( 25811787) Waist circumference ( 23966867) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		328 interacting genes: ABI2 ACLY ACOT11 ACTN3 ADRA2C AHCYL1 AKAP8L ANKRD55 ANTKMT APC APLP2 APP ARFIP2 ARL6IP1 ARMC7 ASB12 ATN1 ATP1A1 ATP2A2 ATXN1L BBC3 BCAS2 BEGAIN BFSP2 BICRAL BLOC1S1 BORCS6 BRINP3 BSG C11orf1 C1orf94 C20orf173 C3orf36 C9orf24 CASK CBS CCDC103 CCDC136 CCDC196 CCDC33 CCND3 CDR2 CDSN CEACAM6 CEP55 CEP57L1 CEP63 CEP68 CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL CYB5R2 DAAM2 DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DNAJC5 DSN1 DTX2 DYDC1 EFHC2 EGFL7 EGFR EHMT2 EIF3F EPS15 ESRRG EXOC3L1 EXOC5 EXOC7 EXOC8 EYA2 FAM166A FAM168A FAM185A FANCG FBN1 FCHSD2 FIGN FLOT1 FLOT2 FNDC11 FOXD4L1 FOXI1 FSD2 FTCD GATC GFAP GFI1B GGA2 GKAP1 GOLGA2 GOLGA6L9 GOLGA7B GUCA1C HAP1 HAUS1 HNRNPDL HNRNPM HSF4 HSFY1 HSPA8 ICA1L IFNA16 IFT74 IL2RB IL4R ILKAP ING5 INTS4 IPO4 JAKMIP2 JMJD7 KIAA0753 KIAA0825 KLF4 KRT13 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT26 KRT27 KRT3 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT6A KRT75 KRT76 KRT82 KRT86 KRTAP19-5 KRTAP26-1 KRTAP7-1 LASP1 LDOC1 LINC00265 LITAF LMO1 LMO4 LRRC61 LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED21 MED22 MED25 MED30 MED4 MED7 MEIS3 MEST MET METTL27 MIF4GD MKNK1 MKRN3 MRFAP1L1 MTHFD1L NADSYN1 NDC80 NDUFB10 NEDD4 NEDD8 NEFL NF2 NFYC NMI NPAS2 NUP54 NUP62 NUTM2F ODAD1 ODAM OIP5 OSBPL5 P4HA3 PAK1 PAX5 PAX6 PEF1 PELP1 PFKM PIK3R1 PITX1 PKNOX2 PLA2G10 PLAAT1 PLCD1 PLD3 PLEKHB2 PMEPA1 PNMA1 POGZ POU2AF1 POU6F2 PPP1R16A PPP1R32 PPP1R7 PPP2R3B PRR22 PRR5 PSMB11 PSMB4 PTCD3 RASSF4 RBCK1 RFC2 RFX6 RHOBTB3 RINT1 RNF4 RPRD1A RPS3A RSPO4 RSU1 RUNX1 SAPCD1 SCAMP3 SCRN1 SCT SDS SERGEF SERTAD3 SF3B3 SMAD2 SMAD3 SMAD5 SMARCB1 SNAP25 SNX1 SNX5 SNX7 SORBS3 SPATA12 SPC25 SPIRE2 SS18L1 STAM STAM2 STK32C STMN3 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TBX19 TCP11L2 TEKT1 TEKT5 TFG TIMM10B TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TP53BP1 TRAF1 TRAF4 TRAK1 TRAP1 TRIM10 TRIM17 TRIM23 TRIM27 TRIM54 TRIM69 TRIM73 TRIML2 TSG101 TUBB TUBB2A UBA1 UBA52 UBAP2 UBB UBC UBE2I UBE4B UBQLN1 UBQLN2 UBQLN4 UBQLNL UBXN11 USHBP1 USP54 VGLL3 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 WASHC1 YPEL3 ZNF302 ZNF34 ZNF430 ZNF44	95 interacting genes: ACTN1 APEX2 APPL1 ARHGAP4 ASCC2 ATXN3 BAALC BAP1 BRCA1 CARD14 CCDC69 CD74 CEP85 CHRM5 CHUK COPS6 CRELD1 CRTC1 CUEDC1 DCUN1D1 DCUN1D2 DENND6B DNAJB2 DNAJB6 DTX1 EPHA1 EPN1 FAF2 FAM184A FKBP6 GGA2 GRIPAP1 GSK3B HBS1L HGS HIP1 IKBKB ILRUN IMPACT KRT36 MAP2K4 MAP2K7 MAPK1 MAPK9 MBP MINDY3 NEK10 NFKBIA NOTCH1 NPLOC4 NR4A1 ODF2 PAK1 PLEKHB2 PSMD4 RAB3IL1 RABEP2 RAD18 RAD23A RAD51AP1 RAF1 RBCK1 RNF114 RNF126 RNF141 SPART STAM STAM2 TAB1 TNIP1 TOM1 TOM1L2 TP53 UBAC1 UBAP1 UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G1 UBE2I UBE2K UBE2L6 UBE2V1 UBE2W UBQLN1 UBXN7 UCHL5 UFD1 USP28 YWHAE ZFAND3 ZFAND5
Entrez ID		9146	4214
HPRD ID		05085	19599
Ensembl ID		ENSG00000185359	ENSG00000095015
Uniprot IDs		A0A0S2Z4R4 O14964	Q13233
PDB IDs		2D3G 3F1I 3OBQ 3ZYQ 4AVX	6WHB
Enriched GO Terms of Interacting Partners?
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