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CCNE2 and CDK3
Data Source:
HPRD
(two hybrid)
CCNE2
CDK3
Description
cyclin E2
cyclin dependent kinase 3
Image
No pdb structure
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Cyclin E1-CDK2 Complex
Cyclin E2-CDK2 Complex
Nucleus
Molecular Function
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Telomere Maintenance
DNA Replication Initiation
Homologous Chromosome Pairing At Meiosis
Mitotic Cell Cycle Phase Transition
Cell Division
Regulation Of Cellular Protein Localization
G1/S Transition Of Mitotic Cell Cycle
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Cell Population Proliferation
G0 To G1 Transition
Cell Division
Regulation Of Cell Cycle
Pathways
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
Association of TriC/CCT with target proteins during biosynthesis
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
Laryngeal cancer
Gastric cancer
GWAS
Interacting Genes
12 interacting genes:
APP
CDK2
CDK3
CDKN1A
CDKN1B
CDKN1C
FBXO7
FBXW7
ORC3
SUMO2
SUMO3
ZDHHC17
39 interacting genes:
APP
CABLES1
CABLES2
CCNA2
CCNC
CCND3
CCNE1
CCNE2
CCNH
CCNI
CDC37
CDKN1A
CDKN1B
CDKN3
CKS1B
CKS2
E2F1
E2F2
E2F3
FOXP2
FRS2
KIR3DL1
LHX3
LHX4
MEOX2
NEDD4L
NELFA
OR2G6
OTX2
PAX5
PAX6
PAX8
PPARA
RACGAP1
RB1
SPDYE4
STN1
TRIM55
TRIM63
Entrez ID
9134
1018
HPRD ID
04801
00446
Ensembl ID
ENSG00000175305
ENSG00000250506
Uniprot IDs
A0A024R9B0
O96020
Q00526
PDB IDs
1LFN
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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