MTA1 and ITGB3BP

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MTA1	ITGB3BP
Description		metastasis associated 1	integrin subunit beta 3 binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Microtubule NuRD Complex Intracellular Membrane-bounded Organelle	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding	Protein Binding Protein C-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Signal Transduction Response To Ionizing Radiation Histone Deacetylation Circadian Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Autoubiquitination	Regulation Of Transcription, DNA-templated Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction CENP-A Containing Nucleosome Assembly Positive Regulation Of Apoptotic Process Cell Division
Pathways		HDACs deacetylate histones SUMOylation of transcription factors ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		45 interacting genes: BCL11A BLOC1S1 CCNH CSNK1G2 CYSRT1 DDX18 DYNLL1 E2F1 ERCC6 ESR1 FHL3 GPR183 GRB2 H3-4 HDAC1 HDAC2 HIF1A ITGB3BP JUN KHDRBS2 KPNA4 KRT31 KRT40 KRTAP10-8 LMO4 LRRK2 LZTS2 MAGEA11 MBD3L2 MNAT1 NACC2 NBPF19 NELFCD NOTCH2NLA PICK1 PLEKHG4 RBBP4 SAT1 SH3GL1 SH3GLB1 SUMO2 TEX11 TP53 TRIM25 UBE2I	41 interacting genes: ACTN2 ANKRD11 APP ARFIP2 C14orf119 CCNA2 CERT1 DDX24 EFHC1 ESR1 GTPBP3 HSF2BP ITGB3 ITGB5 KDM1A KIAA0930 KIFC3 LRRK2 MAPK6 MAPK9 MEIS2 MEOX2 MSGN1 MTA1 NFKB1 NRDE2 NTAQ1 PBX3 PIH1D2 PIK3R3 RECQL5 RXRA RXRG SNAPC5 SUOX SVIL THRA TRIML2 UBR7 USHBP1 USP20
Entrez ID		9112	23421
HPRD ID		04633	09267
Ensembl ID		ENSG00000182979	ENSG00000142856
Uniprot IDs		Q13330 Q9BRL8	D3DQ59 Q13352
PDB IDs		4BKX 4PBY 4PBZ 4PC0 5FXY 5ICN 6G16
Enriched GO Terms of Interacting Partners?
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