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PIAS2 and PGR
Data Source:
BioGRID
(pull down)
PIAS2
PGR
Description
protein inhibitor of activated STAT 2
progesterone receptor
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
PML Body
Nuclear Speck
Chromatin
Nucleoplasm
Mitochondrial Outer Membrane
Cytosol
Molecular Function
RNA Polymerase II Transcription Factor Binding
DNA Binding
Transcription Coregulator Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
SUMO Ligase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Steroid Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Identical Protein Binding
ATPase Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Protein Sumoylation
Negative Regulation Of Androgen Receptor Signaling Pathway
Ovulation From Ovarian Follicle
Epithelial Cell Maturation
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Signal Transduction
Cell-cell Signaling
Negative Regulation Of Gene Expression
Intracellular Steroid Hormone Receptor Signaling Pathway
Paracrine Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Lung Alveolus Development
Regulation Of Epithelial Cell Proliferation
Progesterone Receptor Signaling Pathway
Tertiary Branching Involved In Mammary Gland Duct Morphogenesis
Pathways
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Nuclear signaling by ERBB4
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Estrogen-dependent gene expression
Drugs
Etonogestrel
Desogestrel
Megestrol acetate
Levonorgestrel
Dydrogesterone
Progesterone
Spironolactone
Lindane
Fluticasone propionate
Medroxyprogesterone acetate
Mitotane
Norethisterone
Mometasone
Ethynodiol diacetate
Mifepristone
Norgestimate
Drospirenone
Danazol
Oxybenzone
Allylestrenol
Phthalic Acid
Metribolone
Tanaproget
Telapristone acetate
Asoprisnil
Norelgestromin
Gestodene
Hydroxyprogesterone caproate
Ulipristal
Fluticasone furoate
Dienogest
Medrogestone
Norgestrel
Homosalate
Enzacamene
Gestrinone
Darolutamide
Demegestone
Fluticasone
Mometasone furoate
Segesterone acetate
Diseases
GWAS
Fruit consumption (
32066663
)
Diastolic blood pressure (
30224653
)
Length of menstrual cycle (
30202859
)
Menarche (age at onset) (
25231870
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Interacting Genes
125 interacting genes:
ACY3
ADA
AKT1
AR
ATF2
C1QA
C5orf24
CBS
CBSL
CCHCR1
CCNDBP1
CDCA8
CGGBP1
CHMP4B
CLDN2
CREB1
CREBBP
CTBP1
DDX39B
DES
DEUP1
DMC1
DNMT3A
EDC3
ELK1
ESR1
ESR2
EXOSC8
FAM118B
FKBP6
FLI1
GFAP
GLUL
GOLGA2
GRHL2
GRM8
GTF2I
GTF2IRD1
HDAC3
HMBOX1
HMG20A
HMG20B
HMGXB4
HNRNPCL1
HNRNPUL1
HOMER1
HOOK1
HUWE1
IKZF1
IMPDH1
JUN
KIFC3
LCE1E
LCE2C
LMNA
LMNB1
MAPK8
MAPKAPK2
MBD1
MITF
MLX
MSX2
MX1
MX2
NAV2
NME7
NR3C1
PAICS
PARK7
PAXIP1
PGR
PHC1
PIAS1
PIAS4
PLAG1
PLAGL1
PML
PRKAB2
PRKRA
PRPH
RFX2
RUFY1
RUNX1T1
SEC23A
SIAH1
SIAH2
SMAD3
SMAD4
SNAI2
SNIP1
SOX5
SPATC1L
SPINDOC
SREBF2
STAT4
SUMO1
SUMO1P1
SUMO2
SUMO3
SYN3
TH
TICAM2
TP53
TRAF2
TRAF3
TRAF5
TRIM23
TRIM27
TRIM50
TRIM55
TRIM63
TSR2
TXLNA
UBASH3B
UBE2I
UBE2L3
UBQLN1
ZBED1
ZBTB16
ZBTB8A
ZC3H10
ZFP42
ZNF319
ZNF451
ZNRD2
53 interacting genes:
ANP32A
APEX2
ARID1A
BATF3
BCAS2
BMI1
BRCA1
CCNA1
CCNA2
CDC25B
CDK2
COPS5
CSNK2A1
CUEDC2
DAP3
DDX54
DNAJA1
ESR1
FKBP5
HMGB1
HMGB2
HSPA1A
JDP2
KAT2B
KLF9
NCOA1
NCOA3
NR0B1
PIAS1
PIAS2
PIAS3
POU2F1
POU2F2
PRKDC
PRMT2
RBM23
RBM39
RELA
RNF4
SGTA
SMARCD1
SMARCE1
SNW1
SORBS1
SRC
TAF1B
TDG
TRIM24
UBE3A
UBR5
XRCC5
XRCC6
ZBTB17
Entrez ID
9063
5241
HPRD ID
06944
07077
Ensembl ID
ENSG00000078043
ENSG00000082175
Uniprot IDs
A0A024RC49
O75928
Q2TA77
P06401
PDB IDs
2ASQ
4FO9
1A28
1E3K
1SQN
1SR7
1ZUC
2C7A
2OVH
2OVM
2W8Y
3D90
3G8O
3HQ5
3KBA
3ZR7
3ZRA
3ZRB
4A2J
4APU
4OAR
5CC0
Enriched GO Terms of Interacting Partners
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