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SOCS3 and ACADVL
Data Source:
BioGRID
(pull down)
SOCS3
ACADVL
Description
suppressor of cytokine signaling 3
acyl-CoA dehydrogenase very long chain
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Phosphatidylinositol 3-kinase Complex
Nucleoplasm
Nucleolus
Mitochondrion
Mitochondrial Matrix
Extrinsic Component Of Mitochondrial Inner Membrane
Mitochondrial Membrane
Mitochondrial Nucleoid
Molecular Function
Phosphotyrosine Residue Binding
Protein Kinase Inhibitor Activity
Protein Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Fatty-acyl-CoA Binding
Acyl-CoA Dehydrogenase Activity
Long-chain-acyl-CoA Dehydrogenase Activity
Protein Binding
Very-long-chain-acyl-CoA Dehydrogenase Activity
Identical Protein Binding
Flavin Adenine Dinucleotide Binding
Biological Process
Negative Regulation Of Protein Kinase Activity
Receptor Signaling Pathway Via JAK-STAT
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Intracellular Signal Transduction
Regulation Of Growth
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Post-translational Protein Modification
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Phosphatidylinositol Phosphorylation
Negative Regulation Of Inflammatory Response
Regulation Of Interferon-gamma-mediated Signaling Pathway
Branching Involved In Labyrinthine Layer Morphogenesis
Placenta Blood Vessel Development
Trophoblast Giant Cell Differentiation
Interleukin-6-mediated Signaling Pathway
Cellular Response To Leukemia Inhibitory Factor
Temperature Homeostasis
Fatty Acid Beta-oxidation
Response To Cold
Energy Derivation By Oxidation Of Organic Compounds
Epithelial Cell Differentiation
Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
IRE1-mediated Unfolded Protein Response
Negative Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of Fatty Acid Oxidation
Regulation Of Cholesterol Metabolic Process
Pathways
Interleukin-6 signaling
Signaling by Leptin
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
PTK6 Activates STAT3
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Neddylation
Interferon alpha/beta signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation
XBP1(S) activates chaperone genes
Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Drugs
Diseases
Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS
Asthma (
32296059
)
Blood trace element (Se levels) (
23720494
)
Creatine kinase levels (
29403010
)
Metabolite levels (
23823483
)
Interacting Genes
63 interacting genes:
ABL1
ACADVL
APP
AR
BCL10
BIK
BLK
CSF1R
CSF3R
CSNK1E
CUEDC2
CXCR4
EGFR
ELOB
ELOC
EPOR
ERBB2
ERBB3
ERBB4
GAB1
GFRA1
GHR
HIVEP1
IGF1R
IL12RB2
IL2RB
IL6ST
INSR
IRF7
IRS1
IRS2
JAK1
JAK2
JAK3
KIAA1958
KIT
LEPR
MAP1S
MAPK11
MAPK6
MET
NME4
PDPK1
PIN1
PPP3CB
PRLR
PTK2
PTPN11
RASA1
RBMX
RNF31
RNF7
RPL7A
SH2D2A
SOCS2
TES
TFDP1
TFR2
TRDN
TXK
TXNDC11
YES1
YWHAQ
5 interacting genes:
GPHN
LINC01554
RPSA
SOCS3
TAF1B
Entrez ID
9021
37
HPRD ID
05006
01940
Ensembl ID
ENSG00000184557
ENSG00000072778
Uniprot IDs
O14543
Q6FI39
B3KPA6
P49748
PDB IDs
2UXW
3B96
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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