SPHK1 and RPS6KC1

Data Source:
HPRD (two hybrid, in vivo)

		SPHK1	RPS6KC1
Description		sphingosine kinase 1	ribosomal protein S6 kinase C1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle Presynapse	Lysosome Endosome Early Endosome Membrane
	Molecular Function	Magnesium Ion Binding Lipid Kinase Activity DNA Binding NAD+ Kinase Activity Protein Binding Calmodulin Binding ATP Binding Lipid Binding Sphinganine Kinase Activity Acetyltransferase Activity D-erythro-sphingosine Kinase Activity Sphingosine-1-phosphate Receptor Activity Protein Phosphatase 2A Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Blood Vessel Development Sphingosine-1-phosphate Receptor Signaling Pathway Protein Folding Protein Acetylation Sphingolipid Metabolic Process Sphingosine Metabolic Process Inflammatory Response Brain Development Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Phosphorylation Calcium-mediated Signaling Regulation Of Endocytosis Sphingolipid Biosynthetic Process Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-17 Production Response To Tumor Necrosis Factor Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Contraction Sphingosine Biosynthetic Process Sphingoid Catabolic Process Lipid Phosphorylation Positive Regulation Of Fibroblast Proliferation Regulation Of Phagocytosis Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus DNA Biosynthetic Process Regulation Of Neuroinflammatory Response Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Microglial Cell Activation Regulation Of Endosomal Vesicle Fusion	Protein Phosphorylation Signal Transduction
Pathways		Sphingolipid de novo biosynthesis Association of TriC/CCT with target proteins during biosynthesis VEGFR2 mediated cell proliferation Extra-nuclear estrogen signaling
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)	Breast cancer in childhood cancer survivors ( 29059430) Breast cancer in childhood cancer survivors treated with less than 10 gray radiotherapy ( 29059430) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: BIRC3 CTNND2 CTSB EP300 FYN LYN MBTPS1 RARG RPS6KC1 SPHKAP TRAF2 TRAF6	5 interacting genes: PBX2 PRDX3 SAAL1 SPHK1 VDR
Entrez ID		8877	26750
HPRD ID		04768	10204
Ensembl ID		ENSG00000176170	ENSG00000136643
Uniprot IDs		Q53ZR5 Q9NYA1	A0A087X1U5 F5H7T0 F6RJM5 Q96S38
PDB IDs		3VZB 3VZC 3VZD 4L02 4V24
Enriched GO Terms of Interacting Partners?
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